Objectives: To study the possible change on mode of deaths, medical decision practices, and
family participation on decisions for limiting life-sustaining treatments (L-LST) over a period …

Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

Objective: To describe the incidence of extubation failure and its associated risk factors among
mechanically ventilated children. Method: Prospective cohort study. Children who were …

… collected the data; Mathew Donlan and Patricia Fontela analyzed the data; Patricia Fontela,
… Donlan, Patricia Fontela, and Pramod Puligandla wrote the paper; Patricia Fontela and …

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC)
COVID-19 dataset is one of the largest international databases of prospectively collected …

Background and objectives C-reactive protein (CRP) has been proposed to guide the use of
antibiotics. However, study results are controversial regarding the benefits of such a strategy…

Background Poor methodological quality and reporting are known concerns with diagnostic
accuracy studies. In 2003, the QUADAS tool and the STARD standards were published for …

One-fourth of patients with bronchiolitis seen in US emergency departments between 2007
and 2015 received antibiotics; 70% of them had no documented bacterial coinfection. …

Rationale: Understanding the magnitude of moral distress and its associations may point to
solutions. Objectives: To understand the magnitude of moral distress and other measures of …

Objective To describe management practices and the factors guiding admission and treatment
decisions for viral bronchiolitis across Canadian pediatric intensive care units (PICUs). …