… Firstly, clinical decision rules often do not perform as well in future validation studies as in
their derivation studies (16). This often results from differences in surveillance strategies and …

Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded
fear of bleeding. Drug and food interactions are frequently cited as causes of …

… To satisfy criterion C, we required some indication that medical conditions, especially liver
disease, as well as other drug therapy and diet (notably dietary vitamin K intake) were constant…

Background This article addresses the treatment of VTE disease. Methods We generated
strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), …

Background When ultrasonography is used to investigate deep-vein thrombosis, serial
testing is recommended for those who test negative initially. Serial testing is inconvenient for …

Background Several diagnostic strategies using ultrasound imaging, measurement of D-dimer,
and assessment of clinical probability of disease have proved safe in patients with …

Background: The limitations of the current diagnostic standard, ventilation-perfusion lung
scanning, complicate the management of patients with suspected pulmonary embolism. We …

… The system combined well-established risk factors for venous thrombosis, clinical signs
and symptoms, and determination of whether an alternative diagnosis was likely [12]. We …

… A venogram was normal if both peroneal and posterior tibial veins and the popliteal, superficial
femoral, common femoral, and iliac veins were well opacified. All other test results were …

Background This is the 2nd update to the 9th edition of these guidelines. We provide
recommendations on 17 PICO (Population, Intervention, Comparator, Outcome) questions, four of …