User profiles for P. L. Fox

Paul L Fox

Cleveland Clinic
Verified email at ccf.org
Cited by 17332

Translational control by the 3′-UTR: the ends specify the means

B Mazumder, V Seshadri, PL Fox - Trends in biochemical sciences, 2003 - cell.com
In most cases, translational control mechanisms result from the interaction of RNA-binding
proteins with 5′- or 3′-untranslated regions (UTRs) of mRNA. In organisms ranging from …

The GAIT system: a gatekeeper of inflammatory gene expression

…, J Jia, A Arif, PS Ray, PL Fox - Trends in biochemical …, 2009 - cell.com
Functionally related genes are coregulated by specific RNA–protein interactions that direct
transcript-selective translational control. In myeloid cells, interferon (IFN)-γ induces formation …

Aminoacyl‐tRNA synthetases in medicine and disease

P Yao, PL Fox - EMBO molecular medicine, 2013 - embopress.org
Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous ‘house‐keeping’ enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates …

[HTML][HTML] Apolipoprotein AI is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease

…, D Schmitt, X Fu, L Thomson, PL Fox… - The Journal of …, 2004 - Am Soc Clin Investig
In recent studies we demonstrated that systemic levels of protein-bound nitrotyrosine (NO 2
Tyr) and myeloperoxidase (MPO), a protein that catalyzes generation of nitrating oxidants, …

[HTML][HTML] Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

…, M Sun, PJ Finton, L Shan, B Gugiu, PL Fox… - Journal of Biological …, 2002 - ASBMB
The macrophage scavenger receptor CD36 plays an important role in the uptake of oxidized
forms of low density lipoprotein (LDL) and contributes to lesion development in murine …

An abundant dysfunctional apolipoprotein A1 in human atheroma

…, S Liang, CC Chuang, L Cho, EF Plow, PL Fox… - Nature medicine, 2014 - nature.com
Recent studies have indicated that high-density lipoproteins (HDLs) and their major structural
protein, apolipoprotein A1 (apoA1), recovered from human atheroma are dysfunctional …

[HTML][HTML] Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control

…, V Seshadri, RK Maitra, PE DiCorleto, PL Fox - Cell, 2003 - cell.com
Transcript-specific translational control is generally directed by binding of trans-acting
proteins to structural elements in the untranslated region (UTR) of the target mRNA. Here, we …

[HTML][HTML] Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

CK Mukhopadhyay, B Mazumder, PL Fox - Journal of Biological Chemistry, 2000 - ASBMB
A role of the copper protein ceruloplasmin (Cp) in iron metabolism is suggested by its ferroxidase
activity and by the tissue iron overload in hereditary Cp deficiency patients. In addition, …

TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI

A Chaudhury, GS Hussey, PS Ray, G Jin, PL Fox… - Nature cell …, 2010 - nature.com
Transforming growth factor-β (TGF-β) induces epithelial–mesenchymal transdifferentiation (EMT)
accompanied by cellular differentiation and migration 1 , 2 , 3 , 4 , 5 . Despite extensive …

[HTML][HTML] Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex

…, WHW Tang, JD Smith, EF Plow, PL Fox… - The Journal of …, 2013 - Am Soc Clin Investig
Myeloperoxidase (MPO) and paraoxonase 1 (PON1) are high-density lipoprotein–associated
(HDL-associated) proteins mechanistically linked to inflammation, oxidant stress, and …