5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …

… Alterations in drug efflux due to ABC transporter proteins such as P-glycoprotein (P-gp)
and multi-drug resistance protein (MRP) have been demonstrated in vitro 7, 8. These proteins …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to 'classical' cytotoxic …

Six DNA regions were evaluated as potential DNA barcodes for Fungi, the second largest
kingdom of eukaryotic life, by a multinational, multilaboratory consortium. The region of the …

Ulcerative colitis and Crohn’s disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

… We thank P. Gros for assistance in designing the X-PLOR crystallographic language for …
For the 1+ kHz category, trial numbers versus language outcome, r= 0.75, P -_ 0.01; for 2+ kHz …

Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic
cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, …

… compared with one control (13%; p=1·00). Compared with … (p=0·001), increases in viable
heart mass (p=0·01) and regional contractility (p=0·02), and regional systolic wall thickening (p=…

… Analysis of differential expression from a data set 10 of gene expression in developing fetal
human brain showed a highly significant (P = 5.8 × 10 −9 ) overlap of differentially expressed …

… The promotion effect was also observed with p-xylene as solvent (Table 2). X-ray photoelectron
… EHS, FK, P. Johnston and KG provided discussions and advice on catalyst synthesis. …