User profiles for P. J. MacDonald

Patrick J. Macdonald

Abbott Laboratories
Verified email at abbott.com
Cited by 1305

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission

PJ Macdonald, N Stepanyants, N Mehrotra… - Molecular biology of …, 2014 - Am Soc Cell Biol
The GTPase dynamin-related protein 1 (Drp1) catalyzes mitochondrial division, but the
mechanisms remain poorly understood. Much of what is attributed to Drp1’s mechanism of action …

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

N Stepanyants, PJ Macdonald, CA Francy… - Molecular biology of …, 2015 - Am Soc Cell Biol
Cardiolipin (CL) is an atypical, dimeric phospholipid essential for mitochondrial dynamics in
eukaryotic cells. Dynamin-related protein 1 (Drp1), a cytosolic member of the dynamin …

Ester formation and hydrolysis during wet–dry cycles: generation of far-from-equilibrium polymers in a model prebiotic reaction

I Mamajanov, PJ MacDonald, J Ying… - …, 2014 - ACS Publications
Biopolymers exist within living cells as far-from-equilibrium metastable polymers. Living
systems must constantly invest energy for biopolymer synthesis. In the earliest stages of life on …

Minimum spanning trees of weighted scale-free networks

PJ Macdonald, E Almaas, AL Barabási - Europhysics Letters, 2005 - iopscience.iop.org
A complete characterization of real networks requires us to understand the consequences
of the uneven interaction strengths between a system's components. Here we use minimum …

[HTML][HTML] Distinct splice variants of dynamin-related protein 1 differentially utilize mitochondrial fission factor as an effector of cooperative GTPase activity

PJ Macdonald, CA Francy, N Stepanyants… - Journal of Biological …, 2016 - ASBMB
Multiple isoforms of the mitochondrial fission GTPase dynamin-related protein 1 (Drp1) arise
from the alternative splicing of its single gene-encoded pre-mRNA transcript. Among these, …

APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells

…, RM McDougle, EM Luengas, PJ Macdonald… - Journal of molecular …, 2014 - Elsevier
APOBEC3G belongs to a family of DNA cytosine deaminases that are involved in the restriction
of a broad number of retroviruses including human immunodeficiency virus type 1 (HIV-1)…

Chromophore maturation and fluorescence fluctuation spectroscopy of fluorescent proteins in a cell-free expression system

PJ Macdonald, Y Chen, JD Mueller - Analytical biochemistry, 2012 - Elsevier
Cell-free synthesis, a method for the rapid expression of proteins, is increasingly used to
study interactions of complex biological systems. GFP and its variants have become …

Safety of peripheral administration of vasopressor medications: a systematic review

…, C Smyth, G Keijzers, SPJ Macdonald… - Emergency Medicine …, 2020 - Wiley Online Library
Objective Vasopressor medications have traditionally been administered via central venous
catheters (CVCs), primarily due to concerns of peripheral extravasation of vasoconstrictive …

Recruiting family physicians as participants in research

…, EV DUNN, CT LAMONT, PJ MACDONALD… - Family …, 1989 - academic.oup.com
Obtaining the voluntary participation of family physicians in quality of care research is a
major problem in family practice research. An innovative approach was therefore required to …

Survival time of unfed, first-instar western corn rootworm (Coleoptera: Chrysomelidae) and the effects of soil type, moisture, and compaction on their mobility in soil

PJ Macdonald, CR Ellis - Environmental Entomology, 1990 - academic.oup.com
If soil factors at the time of hatch significantly influence the survival time of newly eclosed
rootworm larvae or their ability to move through the soil to host roots, monitoring significant …