Structure and stereochemistry of the active metabolite of clopidogrel

…, M Maftouh, A Andrieu, MF Uzabiaga, O Fedeli… - Drug metabolism and …, 2002 - ASPET
Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the prevention of vascular thrombotic events in patients at risk. …

Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans

…, V Meunier, F Sadoun, O Fedeli… - Drug metabolism and …, 2008 - ASPET
Midazolam (MDZ) is one of the most commonly used in vivo and in vitro CYP3A4 probe
substrates for drug-drug interactions (DDI) studies. The major metabolic pathway of MDZ in …

Validated method based on immunocapture and liquid chromatography coupled to high-resolution mass spectrometry to eliminate isatuximab interference with M …

…, S Dai, G Finn, S Macé, V Boutet, O Fedeli - Analytical …, 2021 - ACS Publications
In multiple myeloma (MM) disease, malignant plasma cells produce excessive quantities of
a monoclonal immunoglobulin (Ig), known as M-protein. M-protein levels are measured in …

[HTML][HTML] Evaluating isatuximab interference with monoclonal protein detection by immuno-capture and liquid chromatography coupled to high resolution mass …

…, G Engelvin, D DiNoto, H van de Velde, O Fedeli - Blood, 2019 - Elsevier
Recent advances in multiple myeloma (MM), have seen the advent of several therapeutic
monoclonal antibodies (mAb) targeting antigens on malignant plasma cells such as CD38 and …

A sensitive high-resolution mass spectrometry method for quantifying intact M-protein light chains in patients with multiple myeloma

S Muccio, C Hirtz, S Descloux, O Fedeli, S Macé… - Clinica Chimica …, 2024 - Elsevier
To determine the disease status and the response to treatment for patients with multiple
myeloma, measuring serum M-protein levels is a widely used alternative to invasive punctures to …

M-Protein semi-quantification in MM serum patients based on Immuno-Capture and Liquid Chromatography coupled to High Resolution Mass Spectrometry

…, S Macé, DN Deborah, O Fedeli - Clinical …, 2019 - clinical-lymphoma-myeloma …
Background: Daratumumab is an anti-CD38 monoclonal antibody FDA approved for use in
newly diagnosed (NDMM) and relapsed/refractory multiple myeloma (RRMM). A phase 2 trial …

[HTML][HTML] SR-25990C

…, M MAFTOUH, A ANDRIEU, F UZABIAGA, O FEDELI… - ly2874455inhibitor.com
Clopidogrel (SR25990C, PLAVIX) is a potent antiplatelet drug, which has been recently
launched and is indicated for the preven-tion of vascular thrombotic events in patients at risk. …

All-optical low-power 2R regeneration of 10-Gb/s NRZ signals using a III-V on SOI microdisk laser

…, K Vandoorne, N Olivier, JM Fedeli… - IEEE Photonics …, 2013 - ieeexplore.ieee.org
We demonstrate an all-optical low-power 2R regenerator of 10-Gb/s non-return-to-zero data
based on a 10- μm-diameter electrically pumped microdisk laser, which is heterogeneously …

Contribution of the N‐glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans

…, V Meunier, F Sadoun, O Fedeli… - The FASEB …, 2009 - Wiley Online Library
Midazolam is one of the most commonly used in vivo and in vitro CYP3A4 probe substrate
for drug‐drug interactions studies in humans based on the CYP3A4‐mediation of its 1′‐…

Broadband microwave photonic fully tunable filter using a single heterogeneously integrated III-V/SOI-microdisk-based phase shifter

…, S Sales, D Van Thourhout, T Spuesens, N Olivier… - Optics …, 2012 - opg.optica.org
A broadband microwave photonic phase shifter based on a single III-V microdisk resonator
heterogeneously integrated on and coupled to a nanophotonic silicon-on-insulator …