Sulopenem: an intravenous and oral penem for the treatment of urinary tract infections due to multidrug-resistant bacteria
…, MA Zhanel, P Lagacé-Wiens, A Walkty, N Irfan… - Drugs, 2022 - Springer
Sulopenem (formerly known as CP-70,429, and CP-65,207 when a component of a racemic
mixture with its R isomer) is an intravenous and oral penem that possesses in vitro activity …
mixture with its R isomer) is an intravenous and oral penem that possesses in vitro activity …
Lefamulin: a novel oral and intravenous pleuromutilin for the treatment of community-acquired bacterial pneumonia
…, A Golden, L Berry, F Schweizer, MA Zhanel, N Irfan… - Drugs, 2021 - Springer
Lefamulin is a novel oral and intravenous (IV) pleuromutilin developed as a twice-daily
treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic …
treatment for community-acquired bacterial pneumonia (CABP). It is a semi-synthetic …
[HTML][HTML] A controlled quasi-experimental study of an educational intervention to reduce the unnecessary use of antimicrobials for asymptomatic bacteriuria
N Irfan, A Brooks, S Mithoowani, SJ Celetti, C Main… - PLoS …, 2015 - journals.plos.org
Background Asymptomatic bacteriuria (ABU) should only be treated in cases of pregnancy
or in-patients undergoing urologic procedures; however, unnecessary treatment of ABU is …
or in-patients undergoing urologic procedures; however, unnecessary treatment of ABU is …
[HTML][HTML] Real-life experience with IV fosfomycin in Canada: Results from the Canadian LEadership on Antimicrobial Real-life usage (CLEAR) registry
…, A Lee, R Dhami, J Kosar, D Werry, N Irfan… - Journal of Global …, 2023 - Elsevier
Objectives Data on the use of intravenous (IV) fosfomycin in Canada are limited. Using data
captured by the Canadian LEadership on Antimicrobial Real-life usage (CLEAR) registry, …
captured by the Canadian LEadership on Antimicrobial Real-life usage (CLEAR) registry, …
[HTML][HTML] Real-life experience with ceftobiprole in Canada: Results from the CLEAR (CanadianLEadership onAntimicrobialReal-life usage) registry
…, J Kosar, M Baxter, R Dhami, S Borgia, N Irfan… - Journal of Global …, 2021 - Elsevier
Objectives Ceftobiprole is an advanced-generation cephalosporin with a favourable safety
profile. Published data on the clinical use of ceftobiprole are limited. We report use of …
profile. Published data on the clinical use of ceftobiprole are limited. We report use of …
[PDF][PDF] Antimicrobial stewardship in the intensive care setting–a review and critical appraisal of the literature
D Mertz, A Brooks, N Irfan, M Sung - Swiss Medical Weekly, 2015 - smw.ch
BACKGROUND: Many antimicrobial stewardship programmes (ASPs) target the intensive
care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the …
care unit owing to high antimicrobial utilisation. In this review, we summarise and assess the …
In South Africa, a 2-dose Oxford/AZ vaccine did not prevent mild to moderate COVID-19 (cases mainly B. 1.351 variant)
N Irfan, Z Chagla - Annals of Internal Medicine, 2021 - acpjournals.org
Source Citation Madhi SA, Baillie V, Cutland CL, et al. Efficacy of the ChAdOx1 nCoV-19
Covid-19 vaccine against the B. 1.351 variant. N Engl J Med. 2021.[Epub ahead of print.] …
Covid-19 vaccine against the B. 1.351 variant. N Engl J Med. 2021.[Epub ahead of print.] …
Cefazolin versus cloxacillin as definitive antibiotic therapy for methicillin-susceptible Staphylococcus aureus spinal epidural abscess: a retrospective cohort study
Objectives We compared the effectiveness of cefazolin and cloxacillin as definitive antibiotic
therapy for methicillin-susceptible Staphylococcus aureus (MSSA) spinal epidural abscess (…
therapy for methicillin-susceptible Staphylococcus aureus (MSSA) spinal epidural abscess (…
[HTML][HTML] Real-life experience with ceftolozane/tazobactam in Canada: results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry
…, R Dhami, M Baxter, J Kosar, C Cervera, N Irfan… - Journal of Global …, 2021 - Elsevier
Objectives Ceftolozane/tazobactam is a cephalosporin/β-lactamase inhibitor combination with
activity against Gram-negative bacilli. Here we report the use of ceftolozane/tazobactam in …
activity against Gram-negative bacilli. Here we report the use of ceftolozane/tazobactam in …
[HTML][HTML] Meningitis caused by Mycobacterium tuberculosis in a recent immigrant to Canada
AS Komorowski, CKL Lo, N Irfan, N Singhal - CMAJ, 2021 - Can Med Assoc
• In Canada, tuberculous meningitis is an uncommon presentation of Mycobacterium
tuberculosisinfection, occurring most frequently in individuals who arrived to Canada within the …
tuberculosisinfection, occurring most frequently in individuals who arrived to Canada within the …