Tubulointerstitial inflammation and fibrosis are strongly associated with the outcome of
chronic kidney disease. We recently demonstrated that the NOD-like receptor, pyrin domain …

… through interleukin‐1β - Bracey - 2013 - Experimental Physiology - Wiley Online Library …
Nathan Bracey was funded, in part, by an Alberta HEART studentship training award. …

Nucleotide-binding domain and leucine-rich repeat containing PYD-3 (NLRP3) is a pattern
recognition receptor that is implicated in the pathogenesis of inflammation and chronic …

In this work, we find that CD8 + T cells expressing inhibitory killer cell immunoglobulin-like
receptors (KIRs) are the human equivalent of Ly49 + CD8 + regulatory T cells in mice and are …

An 84-year-old woman was referred to our clinic with grey discolouration of her face. She had
a history of hypertension that was managed with amlodipine and olmesartan. She reported …

Significance: Persistent nonmicrobial tissue injury leads to the nonlinear activation of integrated
wound-healing pathways. In chronic cardiovascular diseases, local tissue undergoes …

CD8 T SQa-1shing transplant rejection Page 1 1/9/24, 5:09 AM CD8 Tregs SQa-1shing
transplant rejection | Science Immunology https://www.science.org/doi/10.1126/sciimmunol.adn0644 …

The pryin domain (PYD) domain is involved in protein interactions that lead to assembly of
immune-sensing complexes such as inflammasomes. The repertoire of PYD-containing …

Spatial transcriptomic and proteomic measurements enable high-dimensional characterization
of tissues. However, understanding organizations of cells at different spatial scales and …

A monoclonal antibody targeting CD80 on antigen presenting cells disrupts cisinteractions
with PD-L1, reviving T cell inhibitory checkpoint signaling to suppress autoimmunity.