Reporting bias represents a major problem in the assessment of health care interventions.
Several prominent cases have been described in the literature, for example, in the reporting …

Background The AGREE II instrument is the most commonly used guideline appraisal tool. It
includes 23 appraisal criteria (items) organized within six domains. AGREE II also includes …

Background Access to unpublished clinical study reports (CSRs) is currently being discussed
as a means to allow unbiased evaluation of clinical research. The Institute for Quality and …

More than half of new drugs entering the German healthcare system have not been shown
to add benefit. Beate Wieseler and colleagues argue that international drug development …

Objective To investigate to what extent three types of documents for reporting clinical trials
provide sufficient information for trial evaluation. Design Retrospective analysis Data sources …

Objective: State objective of the review (research question with reference to PICOS). 4
Components of the question: PICOS (participants, interventions, comparisons, outcomes, and …

Background When a new drug becomes available, patients and doctors require information
on its benefits and harms. In 2011, Germany introduced the early benefit assessment of new …

Philip Kranz and colleagues argue that the alleged superior therapeutic benefit attributed to
orphan drugs is often not supported by evidence from clinical trials and propose a reform of …

Background Negative pressure wound therapy (NPWT) is widely applied, although the
evidence base is weak. Previous reviews on medical interventions have shown that conclusions …

Rising drug costs in Germany led to the Act on the Reform of the Market for Medicinal Products
(AMNOG) in January 2011. For new drugs, pharmaceutical companies have to submit …