American Thoracic Society/European Respiratory Society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias

…, I Johnston, DS Kim, N Khalil… - … of respiratory and …, 2002 - mayoclinic.elsevierpure.com
Despite the considerable progress in the classification of the idiopathic interstitial pneumonias
(IIPs), the lack of an international standard has resulted in variable and confusing …

Increased production and immunohistochemical localization of transforming growth factor-b in idiopathic pulmonary fibrosis

N Khalil, RN O'Connor, HW Unruh… - Am J Respir Cell Mol …, 1991 - atsjournals.org
Transforming growth factor-S (TGF-I3) can regulate cell growth and differentiation as well as
production of extracellular matrix proteins. Elevated production ofTGF-13 has been …

Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation.

N Khalil, O Bereznay, M Sporn… - The Journal of …, 1989 - rupress.org
A rat model of bleomycin-induced pulmonary inflammation and fibrosis was used to
examine the relationship between collagen synthesis and transforming growth factor beta (TGF-beta…

[HTML][HTML] TGF-β: from latent to active

N Khalil - Microbes and infection, 1999 - Elsevier
The transforming growth factor-betas (TGF-βs) are synthesized as precursor proteins that
are modified intracellularly prior to secretion. One of the most relevant intracellular …

Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial

…, L Richeldi, J De Andrade, N Khalil… - Annals of internal …, 2013 - acpjournals.org
Chinese translation This article has been corrected. The original version (PDF) is appended
to this article as a Supplement . Background: Idiopathic pulmonary fibrosis (IPF) is …

TGF-beta 1, but not TGF-beta 2 or TGF-beta 3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.

N Khalil, RN O'Connor, KC Flanders… - American journal of …, 1996 - atsjournals.org
Although it is recognized that three isoforms of transforming growth factor-beta (TGF-beta)
exist in mammals, their expression, distribution, and function in injury and repair are not well …

Release of biologically active TGF-β1 by alveolar epithelial cells results in pulmonary fibrosis

…, R O'Connor, G Grotendorst, N Khalil - … of Physiology-Lung …, 2003 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a progressive fatal fibrotic lung disease. Transforming
growth factor (TGF)-β1 is present in a biologically active conformation in the epithelial cells …

[HTML][HTML] Proliferation of pulmonary interstitial fibroblasts is mediated by transforming growth factor-β1-induced release of extracellular fibroblast growth factor-2 and …

N Khalil, YD Xu, R O'Connor, V Duronio - Journal of Biological Chemistry, 2005 - ASBMB
Idiopathic pulmonary fibrosis (IPF; a progressive lung disease) is characterized by
parenchymal remodeling with enlarged air spaces called honeycomb cysts and palisades of …

[HTML][HTML] TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases

G Chen, N Khalil - Respiratory research, 2006 - Springer
Background Airway remodeling in asthma is the result of increased expression of connective
tissue proteins, airway smooth muscle cell (ASMC) hyperplasia and hypertrophy. TGF-β1 …

[HTML][HTML] Pulmonary rehabilitation improves long-term outcomes in interstitial lung disease: a prospective cohort study

…, F Topp, L Hilling, PG Camp, PG Wilcox, N Khalil… - Respiratory …, 2014 - Elsevier
Background Pulmonary rehabilitation improves outcomes in patients with interstitial lung
disease (ILD), however it is unclear whether these effects are long lasting and which patients …