This chapter addresses first one of the key aspects of interpreting findings that is also
fundamental in completing a ‘Summary of findings’ table: the certainty of evidence related to each …

of Findings (SoF) tables present, for each of the seven (or fewer) most important outcomes,
the following: the number of studies and number of participants; the confidence in effect …

Background: Although several tools to evaluate the credibility of health care guidelines exist,
guidance on practical steps for developing guidelines is lacking. We systematically …

Objectives Clear communication of systematic review findings will help readers and decision
makers. We built on previous work to develop an approach that improves the clarity of …

In February 2022, these guidelines were reviewed by an expert work group convened by ASH.
Review included limited searches for new evidence and discussion of the search results. …

Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in
review currency, accuracy, and utility. We are developing a novel approach to systematic …

Background Cervical cancer screening has traditionally been based on cervical cytology.
Given the aetiological relationship between human papillomavirus (HPV) infection and cervical …

Background Guideline developers can: (1) adopt existing recommendations from others; (2)
adapt existing recommendations to their own context; or (3) create recommendations de …

Background Adult patients with diabetes or newly recognized hyperglycemia account for
over 30% of noncritically ill hospitalized patients. These patients are at increased risk for …

When studies measure or report outcomes differently, it may not be feasible to pool data
across studies to generate a single effect estimate (ie, perform meta-analysis). Instead, only a …