… Sticky-ended cohesion is arguably the best example of programmable molecular recognition:
there is significant diversity to possible sticky ends (4 N for N-base sticky ends), and the …

The combination of synthetic stable branched DNA and sticky-ended cohesion has led to
the development of structural DNA nanotechnology over the past 30 years. The basis of this …

… In 1983, Seeman reported that Holliday junctions could be rendered immobile by making
arms with unique sequences and hence lacking the detrimental two-fold symmetry 3 . During …

… the way in which free.energy considerations are taken into account for competing Watson-Crick
pairing interactions (at lengths shorter than NC) will be discussed elsewhere (Seeman & …

Molecular self-assembly presents a ‘bottom-up’ approach to the fabrication of objects specified
with nanometre precision. DNA molecular structures and intermolecular interactions are …

A PRINCIPAL goal of biotechnology is the assembly of novel biomaterials for analytical,
industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched …

The base pairs in double helical nucleic acids have been compared to see how they can be
recognized by proteins. We conclude that a single hydrogen bond is inadequate for …

The 3-angstrom electron density map of crystalline yeast phenylalanine transfer RNA has
provided us with a complete three-dimensional model which defines the positions of all of the …

A grand challenge in the fields of chemistry and materials science is the ability to construct f
the plac or a giv ement of en application. each component in or materials with absolute …

Revised Manuscript Received January 8, 1993 abstract: DNA molecules containing two
crossover sites between helical domainshave been suggested as intermediates in …