FDA approval summary: tagraxofusp-erzs for treatment of blastic plasmacytoid dendritic cell neoplasm
EY Jen, X Gao, L Li, L Zhuang, NE Simpson… - Clinical Cancer …, 2020 - AACR
Tagraxofusp-erzs (Elzonris, Stemline) is a cytotoxin that targets CD123-expressing cells. On
December 21, 2018, FDA approved tagraxofusp-erzs for the treatment of blastic …
December 21, 2018, FDA approved tagraxofusp-erzs for the treatment of blastic …
A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus
SC Shah, J Malone, NE Simpson - New England Journal of …, 1989 - Mass Medical Soc
A period of early, intensive insulin treatment is thought to improve subsequent beta-cell
function in insulin-dependent diabetes mellitus (IDDM). To study this hypothesis, we randomly …
function in insulin-dependent diabetes mellitus (IDDM). To study this hypothesis, we randomly …
FDA approval summary: belantamab mafodotin for patients with relapsed or refractory multiple myeloma
…, G Shen, L Li, L Ma, OO Okusanya, NE Simpson… - Clinical Cancer …, 2022 - AACR
On August 5, 2020, the FDA granted accelerated approval to belantamab mafodotin-blmf (BLENREP;
GlaxoSmithKline) for the treatment of adult patients with relapsed or refractory …
GlaxoSmithKline) for the treatment of adult patients with relapsed or refractory …
Glucose oxidation modulates anoikis and tumor metastasis
…, L Stemboroski, Q Cai, NE Simpson… - … and cellular biology, 2012 - Taylor & Francis
Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic
glycolysis or the Warburg effect, and the cells resist matrix detachment-induced apoptosis, …
glycolysis or the Warburg effect, and the cells resist matrix detachment-induced apoptosis, …
The role of the CaCl2–guluronic acid interaction on alginate encapsulated βTC3 cells
NE Simpson, CL Stabler, CP Simpson, A Sambanis… - Biomaterials, 2004 - Elsevier
Previously we demonstrated that alginate composition has a significant effect on the growth
of encapsulated βTC3 cells and consequently on the overall metabolic and secretory …
of encapsulated βTC3 cells and consequently on the overall metabolic and secretory …
Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage
NE Simpson, KK Kidd, PJ Goodfellow, H McDermid… - Nature, 1987 - nature.com
Multiple endocrine neoplasis type 2A (MEN2A) is one of several kinds of cancers that appear
to be inherited in an autosomally dominant fashion. We have assigned the MEN2A locus to …
to be inherited in an autosomally dominant fashion. We have assigned the MEN2A locus to …
Prenatal diagnosis of genetic disease in Canada: report of a collaborative study.
NE Simpson, L Dallaire, JR Miller… - Canadian Medical …, 1976 - ncbi.nlm.nih.gov
A study of 1223 amniocenteses carried out during 1020 pregnancies in 990 women showed
that 2nd-trimester amniocentesis at about 16 weeks' gestation is a safe, accurate and …
that 2nd-trimester amniocentesis at about 16 weeks' gestation is a safe, accurate and …
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression
NE Simpson, VP Tryndyak, FA Beland… - Breast cancer research …, 2012 - Springer
Epigenetic biomarkers are emerging as determinants of breast cancer prognosis. Breast
cancer cells display unique alterations in major cellular metabolic pathways and it is becoming …
cancer cells display unique alterations in major cellular metabolic pathways and it is becoming …
Novel synthesis of cerium oxide nanoparticles for free radical scavenging
YY Tsai, J Oca-Cossio, K Agering, NE Simpson… - 2007 - Future Medicine
Aims: The aim of this article is to present a novel synthetic route to form CeO 2 nanoparticles
that protects against the detrimental influence of oxidative stress in mammalian cells. …
that protects against the detrimental influence of oxidative stress in mammalian cells. …
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype
NE Simpson, VP Tryndyak, M Pogribna, FA Beland… - Epigenetics, 2012 - Taylor & Francis
The interplay of metabolism and epigenetic regulatory mechanisms has become a focal point
for a better understanding of cancer development and progression. In this study, we have …
for a better understanding of cancer development and progression. In this study, we have …