Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …

Objective To describe the contributions of prescribed and non-prescribed opioids to opioid
related deaths. Design Population based cohort study. Setting Ontario, Canada, from 1 …

Background Omalizumab is indicated for the treatment of moderate to severe asthma. There
is limited observational evidence on the costs and effectiveness of omalizumab. Objective …

Background The COVID-19 pandemic has led to a notable increase in telemedicine adoption.
However, the impact of the pandemic on telemedicine use at a population level in rural …

Importance COVID-19 has had devastating effects on the health and well-being of older
adult residents and health care professionals in nursing homes. Uncertainty about the …

SARS-CoV-2 variants of concern (VOC) are more transmissible and may have the potential
for increased disease severity and decreased vaccine effectiveness. We estimated the …

Importance The incidence of SARS-CoV-2 infection, including among individuals who have
received 2 doses of COVID-19 vaccine, increased substantially following the emergence of …

Objective To estimate the effectiveness of mRNA covid-19 vaccines against symptomatic
infection and severe outcomes (hospital admission or death). Design Test negative design …

Background: The coronavirus disease 2019 (COVID-19) pandemic is thought to have
increased use of virtual care, but population-based studies are lacking. We aimed to assess the …

Background The majority of people with hypertension require more than one medication to
achieve blood pressure control. Many patients are prescribed multipill antihypertensive …