Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Impaired consciousness requires altered cortical function. This can occur either directly from
disorders that impair widespread bilateral regions of the cortex or indirectly through effects …

Haematoma expansion affects a fifth of patients within 24 h of the onset of acute intracerebral
haemorrhage and is associated with death and disability, which makes it an appealing …

Importance Intracerebral hemorrhage (ICH) is a devastating stroke type that lacks effective
treatments. An imaging biomarker of ICH expansion—the computed tomography (CT) …

The 2022 update of the Canadian Stroke Best Practice Recommendations (CSBPR) for
Acute Stroke Management, 7th edition, is a comprehensive summary of current evidence-based …

Background Approximately 40% of patients diagnosed with stroke experience some degree
of aphasia. With limited health care resources, patients’ access to speech and language …

Objective: We hypothesized that low rates of tissue plasminogen activator (tPA) use are only
partially explained by medical considerations, and that biases, beliefs, systems, and …

Introduction Stroke survivors frequently experience a range of post-stroke deficits. Specialized
stroke rehabilitation improves recovery, especially if it is started early post-stroke. However…

Objective We have proposed that three scientific criteria are important for the ethical
justification of randomized clinical trials (RCTs): (1) they should be designed around a clear …

Background and Purpose: Cervical artery dissection (CAD) involving the carotid or vertebral
arteries is an important cause of stroke in younger patients. The purpose of this systematic …