Introduction of molecular HPV testing as the primary technology in cervical cancer screening: Acting on evidence to change the current paradigm

…, W Gotlieb, MH Mayrand, M McLachlin… - Preventive …, 2017 - Elsevier
Since being introduced in the 1940s, cervical cytology – despite its limitations – has had
unequivocal success in reducing cervical cancer burden in many countries. However, we now …

HPV testing in primary cervical screening: a systematic review and meta-analysis

J Murphy, EB Kennedy, S Dunn, CM McLachlin… - Journal of Obstetrics and …, 2012 - Elsevier
Objective Previous findings from cross-sectional studies have shown human papillomavirus
(HPV) testing to be more sensitive than cytology testing for primary cervical screening. This …

Approaches for triaging women who test positive for human papillomavirus in cervical cancer screening

…, W Gotlieb, MH Mayrand, M McLachlin… - Preventive …, 2017 - Elsevier
Substantial evidence exists to support the introduction of molecular testing for human
papillomavirus (HPV) as the primary technology in cervical cancer screening. While HPV testing is …

[HTML][HTML] Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label …

…, A Ferrero, G Artioli, C Davidson, CM McLachlin… - The lancet …, 2018 - thelancet.com
Background Although women with endometrial cancer generally have a favourable prognosis,
those with high-risk disease features are at increased risk of recurrence. The PORTEC-3 …

[HTML][HTML] p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial

…, C Genestie, P Khaw, J Pyman, CM McLachlin… - Modern …, 2022 - nature.com
Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO
and identifies p53-abnormal (p53abn) EC as the subgroup with the poorest prognosis and …

Human papillomavirus in cervical neoplasia: role, risk factors, and implications

CM McLachlin - Clinics in Laboratory Medicine, 2000 - Elsevier
A rapidly increasing body of evidence links human papillomavirus (HPV) to cervical
neoplasia through epidemiologic associations, pathologic features, molecular detection, and …

Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: results from studies of the NCIC Clinical Trials Group …

HJ Mackay, S Gallinger, MS Tsao, CM McLachlin… - European journal of …, 2010 - Elsevier
AIM: The impact of PTEN status and microsatellite instability (MSI) on the prognosis of women
with endometrial cancer is controversial. The aim of this study was to investigate MSI and …

Cervical screening: a guideline for clinical practice in Ontario

J Murphy, EB Kennedy, S Dunn, CM McLachlin… - Journal of obstetrics and …, 2012 - Elsevier
Objective To develop guidelines to inform the Ontario Cervical Screening Program’s invitations
to women in the target population, provide evidence-based clinical practice guidance for …

Report of the 2003 Pan-Canadian Forum on Cervical Cancer Prevention and Control: The recommendations reported herein reflect the decisions of the pan-Canadian …

…, RY Kropp, R Lotocki, V Mai, CM McLachlin… - Journal of Obstetrics and …, 2004 - Elsevier
Objective: To develop evidence-based consensus recommendations on the delivery of cervical
cancer screening, human papillomavirus (HPV) education, HPV testing, and the optimal …

Comparison of ThinPrep and conventional smears in salivary gland fine‐needle aspiration biopsies

JR Parfitt, CM McLachlin… - … International Journal of the …, 2007 - Wiley Online Library
BACKGROUND ThinPrep (TP) cytology for evaluation of nongynecological specimens is being
increasingly used. There are few studies comparing TP with conventional smears (CS) in …