Proopiomelanocortin messenger RNA is decreased in the mediobasal hypothalamus of rats made dependent on ethanol

MN Scanlon, E Lazar‐Wesley… - Alcoholism: Clinical …, 1992 - Wiley Online Library
It is thought that certain actions of ethanol involve an interaction with endogenous opioids,
including proopiomelanocortin‐derived pep‐tides such as β‐endorphin. To examine this …

Exploring physicians' comfort level with opioids for chronic noncancer pain

MN Scanlon, U Chugh - Pain Research and Management, 2004 - hindawi.com
OBJECTIVE: To explore the attitudes of family physicians (FPs) toward the use of opioids in
the management of chronic noncancer pain (CNCP) in the Calgary Health Region (CHR), …

Methods for analyzing and interpreting cooperativity in dose-response curves--I. Antagonist effects on angiotensin receptors in smooth muscle.

GJ Moore, MN Scanlon - General pharmacology, 1989 - europepmc.org
1. Dose-response curves for angiotensins II and III in the rat isolated uterus, portal vein and
aorta, in the absence and presence of the antagonist [Sar1Ile8] ANG II, have been analyzed …

Synthesis and biological activities of analogs of angiotensins II and III containing O-methyltyrosine and D-tryptophan

JM Matsoukas, MH Goghari, MN Scanlon… - Journal of medicinal …, 1985 - ACS Publications
Analogues of angiotensin II and III (ANG II and ANG III) in which the tyrosine and/or
phenylalanine residues were substituted have been synthesized by the solid-phase method and …

A new approach to angiotensin antagonists: methylation of the tyrosine hydroxyl in angiotensin II

MN Scanlon, JM Matsoukas, KJ Franklin, GJ Moore - Life sciences, 1984 - Elsevier
[Sar 1 , Tyr(Me) 4 ] angiotensin II, synthesized by the solid phase method and purified by ion-exchange
chromatography and reversed-phase HPLC, was found to inhibit the contractile …

A cyclic angiotensin antagonist:[1, 8-cysteine) angiotensin II

JM Matsoukas, MN Scanlon… - Journal of medicinal …, 1984 - ACS Publications
[Cys (S-acetamidomethyl) 1, 8] angiotensin II has been synthesizedby the solid-phase
method and purified by car-boxymethylcellulose chromatography and reversed-phase HPLC. …

Rat hypothalamic proopiomelanocortin messenger RNA is unaffected by adrenalectomy

MN Scanlon, E Lazar-Wesley, T Csikos… - … and biophysical research …, 1992 - Elsevier
The negative feedback control of hypothalamic cortocotrophin releasing factor (CRF) and
anterior pituitary proopiomelanocortin (POMC) by corticosteroids is well understood. However, …

Classification of angiotensin receptors in rat isolated uterus, portal vein, and aorta using a slowly dissociating antagonist [Sar1, Ile8] ANG II for receptor blockade

MN Scanlon, GJ Moore - Journal of pharmacological methods, 1988 - Elsevier
Receptor blockade with the slowly dissociating angiotensin (ANG) antagonist, [Sar 1 ,Ile 8 ]ANG
II, was used to determine dissociation constants (K d ) for angiotensins II and III at …

Classification of angiotensin receptors in rat isolated uterus, portal vein, and aorta with the novel competitive antagonist sarmesin

MN Scanlon, GJ Moore - Pharmacology, 1988 - karger.com
Blockade of in vitro contractile responses to angiotensins II and III by the reversible competitive
angiotensin antagonist [Sar 1 , Tyr(Me) 4 ]ANG II (sarmesin) was investigated in 3 rat …

alpha-2-Adrenergic activation of proopiomelanocortin-containing neurons in the arcuate nucleus causes opioid-mediated hypotension and bradycardia

SJ Li, MN Scanlon, Z Jįrai, K Varga… - …, 1996 - karger.com
Abstract Treatment of rats for 4 days with α-methyldopa, 200 mg/kg/day ip, increases steady
state levels of proopiomelanocortin (POMC) mRNA in the mediobasal hypothalamus, as …