Self-collected saline gargle samples as an alternative to health care worker-collected nasopharyngeal swabs for COVID-19 diagnosis in outpatients

…, A Pabbi, S Hannam-Clark, M Charles… - Journal of clinical …, 2021 - Am Soc Microbiol
We assessed the performance, stability, and user acceptability of swab-independent self-collected
saliva and saline mouth rinse/gargle sample types for the molecular detection of …

Evaluation of the BioFireŽ COVID-19 test and Respiratory Panel 2.1 for rapid identification of SARS-CoV-2 in nasopharyngeal swab samples

…, K Locher, M Caza, L Li, V Lavergne, M Charles - … and infectious disease, 2021 - Elsevier
The BioFireŽ COVID-19 Test and Respiratory Panel 2.1 (RP2.1) are rapid, fully automated
assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in …

Legionella micdadei brain abscess

M Charles, E Johnson, A Macyk-Davey… - Journal of Clinical …, 2013 - Am Soc Microbiol
… Authors: Marthe Charles, Edward Johnson, Andrea Macyk-Davey, Monica Henry, Jan-Erik
Nilsson, Lil Miedzinski, George Zahariadis… Marthe Charles … Address correspondence to …

[HTML][HTML] Nanopore metagenomic sequencing for detection and characterization of SARS-CoV-2 in clinical samples

…, C Nelson, MB Bonsall, K Locher, M Charles… - PLoS …, 2021 - journals.plos.org
Objectives The COVID-19 pandemic has underscored the need for rapid novel diagnostic
strategies. Metagenomic Next-Generation Sequencing (mNGS) may allow for the detection of …

[HTML][HTML] Alterations in the nasopharyngeal microbiome associated with SARS-CoV-2 infection status and disease severity

…, K Locher, C MacDonald, SD Chorlton, M Charles… - PLoS …, 2022 - journals.plos.org
Objectives The COVID-19 pandemic and ensuing public health emergency has emphasized
the need to study SARS-CoV-2 pathogenesis. The human microbiome has been shown to …

[HTML][HTML] BugSplit enables genome-resolved metagenomics through highly accurate taxonomic binning of metagenomic assemblies

…, C Nelson, MB Bonsall, K Locher, M Charles… - Communications …, 2022 - nature.com
A large gap remains between sequencing a microbial community and characterizing all of the
organisms inside of it. Here we develop a novel method to taxonomically bin metagenomic …

[HTML][HTML] SARS-CoV-2 serology: Validation of high-throughput chemiluminescent immunoassay (CLIA) platforms and a field study in British Columbia

…, D Cook, B Bates, L Burns, S Masud, M Charles… - Journal of Clinical …, 2021 - Elsevier
Background SARS-CoV-2 antibody testing is required for estimating population seroprevalence
and vaccine response studies. It may also increase case identification when used as an …

First reported outbreak of the emerging pathogen Candida auris in Canada

…, L Hoang, M Dawar, M Charles - American Journal of …, 2021 - Elsevier
Background Candida auris was first described in Japan in 2009 and has since been detected
in over 40 countries. The yeast is concerning for multiple reasons, primarily: (1) challenges …

An engineered nanocomposite copper coating with enhanced antibacterial efficacy

…, B Velapatino, EA Bryce, MK Charles… - Advanced Materials …, 2022 - Wiley Online Library
Contaminated surfaces are a major source of nosocomial infection. To reduce microbial
bioburden and surface‐based transmission of infectious disease, the use of antibacterial and self…

[HTML][HTML] A nested cohort 5-year Canadian surveillance of Gram-negative antimicrobial resistance for optimized antimicrobial therapy

J Blondeau, MK Charles, V Loo, H Adam… - Scientific Reports, 2023 - nature.com
We analyzed 5 years (2016–2020) of nested Canadian data from the Study for Monitoring
Antimicrobial Resistance Trends (SMART) to identify pathogen predominance and …