Background Long working hours might increase the risk of cardiovascular disease, but
prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We …

A hypothesis concerning habitual sleep reduction and its adverse consequences among
general population in modern societies has received wide publicity in the mass media, …

BackgroundAdverse psychosocial working environments characterized by job strain (the
combination of high demands and low control at work) are associated with an increased risk of …

Background The contribution of hereditary factors to the causation of sporadic cancer is
unclear. Studies of twins make it possible to estimate the overall contribution of inherited genes …

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Objective Twin concordance data for rheumatoid arthritis (RA) on their own provide only
limited insight into the relative genetic and environmental contribution to the disease. We …

Background Published work assessing psychosocial stress (job strain) as a risk factor for
coronary heart disease is inconsistent and subject to publication bias and reverse causation …

We studied the cumulative incidence, concordance rate and heritability for diabetes mellitus
in a nationwide cohort of 13,888 Finnish twin pairs of the same sex. The twins were born …

The association of snoring with ischaemic heart disease and stroke was studied prospectively
in 4388 men aged 40-69. The men were asked, in a questionnaire sent to them, whether …

Context.—Physical activity and fitness are believed to reduce premature mortality, but whether
genetic factors modify this effect is not known.Objective.—To investigate leisure physical …