User profiles for Mark Clemons
Mark ClemonsThe Ottawa Hospital, Ottawa, Ontario Verified email at toh.on.ca Cited by 21031 |
Estrogen and the risk of breast cancer
M Clemons, P Goss - New England Journal of Medicine, 2001 - Mass Medical Soc
The connection between breast cancer and estrogen has been recognized for more than
100 years, since George Beatson demonstrated that bilateral oophorectomy resulted in the …
100 years, since George Beatson demonstrated that bilateral oophorectomy resulted in the …
Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label …
…, K Tonkin, H Hirte, D Huntsman, M Clemons… - The lancet …, 2011 - thelancet.com
Background Olaparib (AZD2281) is a small-molecule, potent oral poly(ADP-ribose) polymerase
(PARP) inhibitor. We aimed to assess the safety and tolerability of this drug in patients …
(PARP) inhibitor. We aimed to assess the safety and tolerability of this drug in patients …
[PDF][PDF] PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer
Metabolic reprogramming is a hallmark of cellular transformation, yet little is known about
metabolic changes that accompany tumor metastasis. Here we show that primary breast …
metabolic changes that accompany tumor metastasis. Here we show that primary breast …
Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design
Background Clinical experience suggests that many women with triple-negative metastatic
breast cancer (MBC) relapse quickly. This has implications for clinical practice and trial design…
breast cancer (MBC) relapse quickly. This has implications for clinical practice and trial design…
Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a …
…, Z Jiang, CL Arteaga, W Jonat, M Clemons… - The Lancet …, 2017 - thelancet.com
Background Phosphatidylinositol 3-kinase (PI3K) pathway activation is a hallmark of endocrine
therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed …
therapy-resistant, hormone receptor-positive breast cancer. This phase 3 study assessed …
[HTML][HTML] Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer
…, A Laupacis, IF Tannock, M Clemons - Journal of clinical …, 2012 - ncbi.nlm.nih.gov
Purpose Decisions about treatment for women with metastatic breast cancer are usually based
on the estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor …
on the estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor …
Cognitive function, fatigue, and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancer
…, QL Yi, H Hu, I Chemerynsky, M Clemons… - Journal of clinical …, 2003 - ascopubs.org
Purpose: There is evidence that cognitive dysfunction, fatigue, and menopausal symptoms
may occur in women receiving adjuvant chemotherapy for breast cancer. Here, we determine …
may occur in women receiving adjuvant chemotherapy for breast cancer. Here, we determine …
Perivascular M2 macrophages stimulate tumor relapse after chemotherapy
Tumor relapse after chemotherapy-induced regression is a major clinical problem, because
it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are …
it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are …
[PDF][PDF] Randomized phase II study comparing two schedules of everolimus in patients with recurrent/metastatic breast cancer: NCIC Clinical Trials Group IND. 163.
SL Ellard, M Clemons, KA Gelmon, B Norris… - Clin Oncol, 2009 - researchgate.net
… Certain relationships marked with a “U” are those for which no compensation was received;
those relationships marked with a “C” were compensated. For a detailed description of the …
those relationships marked with a “C” were compensated. For a detailed description of the …
Tamoxifen ('Nolvadex'): a review: Antitumour treatment
Tamoxifen has been used in the management of breast cancer for over 30 years. Since its
introduction for the treatment of advanced breast cancer, its indications have increased to …
introduction for the treatment of advanced breast cancer, its indications have increased to …