Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at
risk of developing type 2 diabetes, cardiovascular disease and related metabolic and …

Genome-wide association studies have identified numerous loci linked with complex diseases,
for which the molecular mechanisms remain largely unclear. Comprehensive molecular …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …

Telomere length (TL) has been associated with aging and mortality, but individual differences
are also influenced by genetic factors, with previous studies reporting heritability estimates …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

We conducted a sib pair study in very old subjects for the purpose of mapping longevity loci.
In the present analysis, we explore whether our recruitment strategy has resulted in a …