Clostridium difficile infection in the intensive care unit

MA Leclair, C Allard, O Lesur… - Journal of intensive care …, 2010 - journals.sagepub.com
Clostridium difficile infection (CDI) is an increasing nosocomial problem in North America and
Western Europe, where outbreaks caused by a more virulent, toxin-hyperproducing strain …

[HTML][HTML] Acute generalized exanthematous pustulosis with severe organ dysfunction

MA Leclair, B Maynard, C St-Pierre - CMAJ, 2009 - Can Med Assoc
Discussion Severe drug-induced skin reactions are a major diagnostic challenge. Stevens–Johnson
syndrome and toxic epidermal necrolysis are well-described entities.(Stevens–…

Prescribed targets for titration of vasopressors in septic shock: a retrospective cohort study

…, G Guyatt, M Meade, Q Zhou, MA Leclair… - … Open Access Journal, 2013 - cmajopen.ca
Background Without robust clinical evidence to guide titration of vasopressors in septic
shock, it is unclear how dosing of these potent medications occurs. We sought to measure the …

[HTML][HTML] High-dose vitamin-C induced prolonged factitious hyperglycemia in a peritoneal dialysis patient: a case report

…, JF Bilodeau, F Lamontagne, MA Leclair - Journal of Medical Case …, 2021 - Springer
Background High-dose vitamin C is increasingly used for sepsis and more recently for
coronavirus disease 2019 (COVID-19) infections. Proponents argue that the low cost and near …

Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial

…, F D'Aragon, C St-Arnaud, M Mayette, MA Leclair… - BMJ open, 2020 - bmjopen.bmj.com
Introduction Vasodilatory hypotension is common among intensive care unit (ICU) patients;
vasopressors are considered standard of care. However, optimal mean arterial pressure (…

[PDF][PDF] Vasopressor stewardship: a case report and lessons shared

…, NKJ Adhikari, MOM MD, D Bérard, MA Leclair… - Dynamics, 2014 - cjccn.ca
A case report, focused on vasopressor use and presented in this article, is likely to resonate
with many critical care nurses. In this article the authors describe opportunities to enhance …

[HTML][HTML] Vasopressor use following traumatic injury–A single center retrospective study

…, SK Mayer, WD Fraser, A Vanasse, MA Leclair… - PLoS …, 2017 - journals.plos.org
Objectives Vasopressors are not recommended by current trauma guidelines, but recent
reports indicate that they are commonly used. We aimed to describe the early hemodynamic …

[HTML][HTML] Protocol: Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial

…, F D'Aragon, C St-Arnaud, M Mayette, MA Leclair… - BMJ Open, 2020 - ncbi.nlm.nih.gov
Introduction Vasodilatory hypotension is common among intensive care unit (ICU) patients;
vasopressors are considered standard of care. However, optimal mean arterial pressure (…

[PDF][PDF] Confidential

…, A Bersten, G Guyatt, M Meade, Q Zhou, MA Leclair… - cmajopen.ca
Background: Without robust clinical evidence to guide vasopressor titration in septic shock,
it is unclear who adjusts the dosing of these potent medications and how. We hypothesized …

Outcome issues of mechanical ventilator settings in acute respiratory distress syndrome patients from Québec ICUs after the 2000 Acute Respiratory Distress …

Y Poulin, MA Leclair, F Lauzier… - Journal of Organ …, 2008 - Taylor & Francis
Objective. To undertake a retrospective assessment of a knowledge translation of how a low
tidal volume setting has affected the overall outcome of acute lung injury (ALI)/acute …