Poly(ADP-ribose) polymerase 1 (PARP-1) regulates gene transcription, cell death signaling,
and DNA repair through production of the posttranslational modification poly(ADP-ribose). …

Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates
many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-…

Poly(ADP-ribose) polymerase–1 (PARP-1) (ADP, adenosine diphosphate) has a modular
domain architecture that couples DNA damage detection to poly(ADP-ribosyl)ation activity …

ADP-ribosylation of proteins regulates protein activities in various processes including
transcription control, chromatin organization, organelle assembly, protein degradation, and DNA …

Poly(ADP-ribose) polymerase-1 (PARP-1) creates the posttranslational modification PAR
from substrate NAD + to regulate multiple cellular processes. DNA breaks sharply elevate …

… mm Tris-HCl, pH 7.0, 150 mm NaCl, 0.1 mm TCEP, and 1 mm EDTA and eluted with a gradient
from 150 mm to 1 m … 50 mm NaCl, and the elution gradient was 50 mm to 500 mm NaCl. …

Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in
seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. A burst of …

Poly(ADP-ribose) polymerase-1 (PARP-1) has two homologous zinc finger domains, Zn1 and
Zn2, that bind to a variety of DNA structures to stimulate poly(ADP-ribose) synthesis activity …

PARP-1, PARP-2 and PARP-3 are DNA-dependent PARPs that localize to DNA damage,
synthesize poly(ADP-ribose) (PAR) covalently attached to target proteins including themselves…

INTRODUCTION Poly(ADP-ribose) polymerase–1 (PARP-1) is an abundant enzyme in the
cell nucleus that regulates genome repair by binding to DNA damage sites and creating the …