… Research studies conducted in the laboratory of MH Perdue are funded by the Canadian
Institutes for Health Research and the Crohn's and Colitis Foundation of Canada. JD …

Central corticotrophin releasing‐factor (CRF) signalling pathways are involved in the endocrine,
behavioural and visceral responses to stress. Recent studies indicate that peripheral …

… Sprague Dawley rats normally do not develop stress-induced alterations in mucosal function
(Saunders and Perdue, unpublished observations); however, exposure to daily separation …

Background: We previously showed that neonatal maternal separation (MS) of rat pups
causes immediate and long-term changes in intestinal physiology. Aim: To examine if …

Background and aim: Chronic psychological stress, including water avoidance stress (WAS),
induces intestinal mucosal barrier dysfunction and impairs mucosal defences against …

Background & Aims: Chronic psychological stress is an important factor in relapses of
intestinal disorders, but it remains unclear if stress can induce primary gut inflammation in a …

BACKGROUND AND AIMS Stress may be an important factor in exacerbating inflammatory
bowel disease but the underlying mechanism is unclear. Defective epithelial barrier function …

BACKGROUND AND AIMS Glucagon-like peptide-2 (GLP-2) is a recently identified potent
intestinotrophic factor. We have evaluated the effect of GLP-2 treatment on intestinal epithelial …

… DM MCKAY, AND MH PERDUE Intestinal Disease Research Program, Department … Kosecka,
DM McKay, and MH Perdue. Acute stressors stimulate ion secretion and … and MH Perdue. …

Gastrointestinal symptoms occur in a large number of patients with food allergies. Immediate
hypersensitivity mechanisms may give rise to the nausea, vomiting, abdominal pain, and …