The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's
lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the …

Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and-independent
manner during apoptosis. Here, we report that the gene for caspase 8 is frequently …

… 150 kb nested within a larger deletion of ≈3 Mb in patient A (see Fig. 1A… We therefore
extended our analysis to the 3-Mb deletion in … Analysis of genomic sequences approximately 1 Mb …

Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing
skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal …

A t (3; 5)(q25. 1; q34) chromosomal translocation associated with myelodysplastic syndrome
and acute myeloid leukemia (AML) was found to rearrange part of the nucleophosmin (NPM…

Retroviral activation of Evi-1 gene expression is one of the most common transforming
events in murine myeloid leukemias. To evaluate the role of the EVI1 gene in human acute …

Lineage-ambiguous leukemias pose significant diagnostic and therapeutic challenges due
to a poorly understood molecular and cellular basis. We identify oncogenic deregulation of …

Existing recombinant adeno-associated virus (rAAV) serotypes for delivering in vivo gene
therapy treatments for human liver diseases have not yielded combined high-level human …

Acquired chromosomal rearrangements in acute nonlymphocytic leukemia (ANLL) have
been linked to specific clinicopathologic features that suggest new disease subtypes. In this …

We defined the spectrum of mutations in relapsed pediatric AML and identified UBTF -TDs
as a new recurrent genetic alteration. These duplications are more common in children and …