We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)–associated
coronavirus known as the Tor2 isolate. The genome sequence reveals that this …

The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths
worldwide 1 . The 1918 virus is also highly pathogenic in mice, and studies have identified a …

Vaccines and therapies are urgently needed to address public health needs stemming from
emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) …

Without an approved vaccine or treatments, Ebola outbreak management has been limited
to palliative care and barrier methods to prevent transmission. These approaches, however, …

Background Recent importation of Lassa fever into Germany, the Netherlands, the United
Kingdom, and the United States by travelers on commercial airlines from Africa underscores …

Ebola viruses are highly lethal human pathogens that have received considerable attention
in recent years due to an increasing re-emergence in Central Africa and a potential for use …

We have created a library of 2007 mutagenized Caenorhabditis elegans strains, each
sequenced to a target depth of 15-fold coverage, to provide the research community with mutant …

Widespread circulation of SARS-CoV-2 in humans raises the theoretical risk of reverse
zoonosis events with wildlife, reintroductions of SARS-CoV-2 into permissive nondomesticated …

Background Effective countermeasures are urgently needed to prevent and treat infections
caused by highly pathogenic and biological threat agents such as Marburg virus (MARV). We …

Background Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans
and non-human primates. Methodology/Principal Findings We demonstrate that the VSVΔG/…