Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Context Between March and July 2009, the largest number of confirmed cases of 2009
influenza A(H1N1) infection occurred in North America. Objective To describe characteristics, …

Background Mesenchymal stromal cells (MSCs, “adult stem cells”) have been widely used
experimentally in a variety of clinical contexts. There is interest in using these cells in critical …

Importance Hydroxyethyl starch is commonly used for volume resuscitation yet has been
associated with serious adverse events, including acute kidney injury and death. Clinical trials …

Background The appropriate caloric goal for critically ill adults is unclear. We evaluated the
effect of restriction of nonprotein calories (permissive underfeeding), as compared with …

Background Fresh red cells may improve outcomes in critically ill patients by enhancing
oxygen delivery while minimizing the risks of toxic effects from cellular changes and the …

Background: Glycemic control is increasingly being recognized as a priority in the treatment
of critically ill patients. Titration and monitoring of insulin infusions involve frequent blood …

Introduction Plusieurs strategies ont ete proposees pour le contrôle de la douleur postoperatoire.
Parmi ces strategies, la lidocaıne par voie intraveineuse suscite un intereˆt croissant. …

ContextThe benefits of therapeutic hypothermia as a treatment for traumatic brain injury (TBI)
remain unclear.ObjectiveTo explore the effects of depth, duration, and rate of rewarming …