Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell
death that is thought to involve aberrant immune responses. Here we investigated the role of …

The sterol regulatory element binding protein (SREBP) family of transcription activators are
critical regulators of cholesterol and fatty acid homeostasis 1 , 2 . We previously …

The molecular signature and functional properties of astroglial subtypes in the adult CNS
remain largely undefined. By using translational ribosome affinity purification followed by RNA-…

Granule neurons generated in the adult mammalian hippocampus synaptically integrate to
facilitate cognitive function and antidepressant efficacy. Here, we investigated the role of …

Background: Many patients taking statins often complain of muscle pain and weakness. The
extent to which muscle pain reflects muscle injury is unknown. Methods: We obtained …

Mammalian Chk1 and Chk2 are two Ser/Thr effector kinases that play critical roles in DNA
damage-activated cell cycle checkpoint signaling pathways downstream of ataxia …

The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳s
disease (PD) is characterized by disturbed gene expression networks. Micro(mi)RNAs are …

Background— Clinical trial and epidemiological data support that the cardiovascular effects
of estrogen are complex, including a mixture of both potentially beneficial and harmful effects…

Objective— Aldosterone (Aldo) antagonism prevents cardiovascular mortality by unclear
mechanisms. Aldo binds to the mineralocorticoid receptor (MR), a ligand-activated transcription …

Glioblastoma multiforme (GBM) is an aggressive brain tumor for which there is no cure.
Overexpression of wild-type epidermal growth factor receptor (EGFR) and loss of the tumor …