User profiles for Lakshmanan Iyer
Lakshmanan K. IyerResearch Assistant Professor Verified email at tufts.edu Cited by 3268 |
[HTML][HTML] Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
…, CE Doykan, PM Wu, RR Gali, LK Iyer… - The Journal of …, 2012 - Am Soc Clin Investig
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell
death that is thought to involve aberrant immune responses. Here we investigated the role of …
death that is thought to involve aberrant immune responses. Here we investigated the role of …
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
…, R Mako Saito, SG Hyberts, S Yang, C Macol, L Iyer… - Nature, 2006 - nature.com
The sterol regulatory element binding protein (SREBP) family of transcription activators are
critical regulators of cholesterol and fatty acid homeostasis 1 , 2 . We previously …
critical regulators of cholesterol and fatty acid homeostasis 1 , 2 . We previously …
Molecular and functional properties of regional astrocytes in the adult brain
…, H Higashimori, T Shoneye, LK Iyer… - Journal of …, 2017 - Soc Neuroscience
The molecular signature and functional properties of astroglial subtypes in the adult CNS
remain largely undefined. By using translational ribosome affinity purification followed by RNA-…
remain largely undefined. By using translational ribosome affinity purification followed by RNA-…
Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus
JP Chan, J Cordeira, GA Calderon, LK Iyer… - Molecular and Cellular …, 2008 - Elsevier
Granule neurons generated in the adult mammalian hippocampus synaptically integrate to
facilitate cognitive function and antidepressant efficacy. Here, we investigated the role of …
facilitate cognitive function and antidepressant efficacy. Here, we investigated the role of …
Association between statin-associated myopathy and skeletal muscle damage
Background: Many patients taking statins often complain of muscle pain and weakness. The
extent to which muscle pain reflects muscle injury is unknown. Methods: We obtained …
extent to which muscle pain reflects muscle injury is unknown. Methods: We obtained …
[HTML][HTML] Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach
T O'Neill, L Giarratani, P Chen, L Iyer, CH Lee… - Journal of Biological …, 2002 - ASBMB
Mammalian Chk1 and Chk2 are two Ser/Thr effector kinases that play critical roles in DNA
damage-activated cell cycle checkpoint signaling pathways downstream of ataxia …
damage-activated cell cycle checkpoint signaling pathways downstream of ataxia …
Midbrain dopamine neurons in Parkinson׳ s disease exhibit a dysregulated miRNA and target-gene network
The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳s
disease (PD) is characterized by disturbed gene expression networks. Micro(mi)RNAs are …
disease (PD) is characterized by disturbed gene expression networks. Micro(mi)RNAs are …
Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury
Background— Clinical trial and epidemiological data support that the cardiovascular effects
of estrogen are complex, including a mixture of both potentially beneficial and harmful effects…
of estrogen are complex, including a mixture of both potentially beneficial and harmful effects…
Aldosterone regulates vascular gene transcription via oxidative stress–dependent and–independent pathways
BG Newfell, LK Iyer, NN Mohammad… - … and Vascular Biology, 2011 - Am Heart Assoc
Objective— Aldosterone (Aldo) antagonism prevents cardiovascular mortality by unclear
mechanisms. Aldo binds to the mineralocorticoid receptor (MR), a ligand-activated transcription …
mechanisms. Aldo binds to the mineralocorticoid receptor (MR), a ligand-activated transcription …
Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme
…, RT Bronson, R Pfannl, F White, DE Housman, L Iyer… - Oncogene, 2012 - nature.com
Glioblastoma multiforme (GBM) is an aggressive brain tumor for which there is no cure.
Overexpression of wild-type epidermal growth factor receptor (EGFR) and loss of the tumor …
Overexpression of wild-type epidermal growth factor receptor (EGFR) and loss of the tumor …