Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses

LJ Brandes, RJ Arron, RP Bogdanovic, J Tong… - Cancer research, 1992 - AACR
Brandes, LJ, and Hermonat, MW A diphcnylmethane derivative specific for the antiestrogen
Brandes, LJ, LaBella, FS, and Warrington, RC Increased therapeutic index of antineoplastic …

SimpleBox 2.0: a nested multimedia fate model for evaluating the environmental fate of chemicals

LJ Brandes, H Den Hollander - 1996 - rivm.openrepository.com
SimpleBox is a nested multimedia box model of the 'Mackay type'. The environment is modeled
as consisting of a set of well-mixed homogeneous compartments (air, fresh water, sea …

Histamine is an intracellular messenger mediating platelet aggregation

SP Saxena, LJ Brandes, AB Becker, KJ Simons… - Science, 1989 - science.org
Inhibition of human platelet aggregation by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine-HCl
(DPPE), a novel antagonist of histamine binding, suggested that histamine might …

Receptor status and subsequent sensitivity of subclones of MCF-7 human breast cancer cells surviving exposure to diethylstilbestrol

LJ Brandes, MW Hermonat - Cancer research, 1983 - AACR
The estrogen receptor (ER)-positive human breast cancer cell line MCF-7 was incubated
continuously in the presence of pharmacological concentrations of diethylstilbestrol (DES) in …

Interaction of histamine and other bioamines with cytochromes P450: implications for cell growth modulation and chemopotentiation by drugs

FS LaBella, LJ Brandes - Seminars in cancer biology, 2000 - Elsevier
We have characterized microsomal and nuclear histamine sites, designated H IC , through
which this amine acts as an intracellular mediator of platelet aggregation and lymphocyte …

Enhanced Cancer Growth in Mice Administered Daily Human-Equivalent Doses of Some H1-Antihistamines: Predictive In Vitro Correlates

LJ Brandes, RC Warrington, RJ Arron… - JNCI: Journal of the …, 1994 - academic.oup.com
Background Present studies of drug-induced tumor growth promotion have evolved from
earlier investigations into the mechanism of action of N,N-di-ethyl-2-[4-(phenylmethyl)phenoxy]…

Evidence that the antiestrogen binding site is a histamine or histamine-like receptor

LJ Brandes, LM Macdonald, RP Bogdanovic - Biochemical and biophysical …, 1985 - Elsevier
N,N-diethyl-2-[(4 phenylmethyl)-phenoxy]-ethanamine·HCl(DPPE), a compound selective
for the antiestrogen binding site, is structurally similar to the aminoethyl ether group of …

Hormetic effects of hormones, antihormones, and antidepressants on cancer cell growth in culture: in vivo correlates

LJ Brandes - Critical Reviews in Toxicology, 2005 - Taylor & Francis
Evidence is presented that the ability of hormones and antihormones to cause biphasic (hormetic)
proliferative responses in cancer cells in vitro correlates with a similar effect of these …

Enhancement of tumor growth by drugs with some common molecular actions

FS LaBella, LJ Brandes - … in cooperation with the University of …, 1996 - Wiley Online Library
Brandes LJ, LaBella FS. Histamine and calcium are independently regulated intracellular …
Kroeger EA, Brandes LJ. Evidence that tamoxifen is a histamine antagonist. Biochern …

Increased therapeutic index of antineoplastic drugs in combination with intracellular histamine antagonists

LJ Brandes, FS LaBella… - JNCI: Journal of the …, 1991 - academic.oup.com
L-Histidinol, a Protein synthesis inhibitor and structural analogue of L-histidine, has been
demonstrated in chemotherapy-treated mice to be cytoprotective to normal stem cells but to …