Background The full complement of DNA mutations that are responsible for the pathogenesis
of acute myeloid leukemia (AML) is not yet known. Methods We used massively parallel …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Most mutations in cancer genomes are thought to be acquired after the initiating event,
which may cause genomic instability and drive clonal evolution. However, for acute myeloid …

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …

The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged from a
common ancestor roughly 100 million years ago and yet are almost indistinguishable by eye. …

The adult human intestine contains trillions of bacteria, representing hundreds of species
and thousands of subspecies. Little is known about the selective pressures that have shaped …

‘Orang-utan’ is derived from a Malay term meaning ‘man of the forest’ and aptly describes the
southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo …

Cholangiocarcinoma (CCA) is an aggressive malignancy of the bile ducts, with poor
prognosis and limited treatment options. Here, we describe the integrated analysis of somatic …

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic
diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue …

Human chromosome 7 has historically received prominent attention in the human genetics
community, primarily related to the search for the cystic fibrosis gene and the frequent …