Directed differentiation protocols enable derivation of cardiomyocytes from human pluripotent
stem cells (hPSCs) and permit engineering of human myocardium in vitro. However, hPSC-…

We report the fabrication of a scaffold (hereafter referred to as AngioChip) that supports the
assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, …

Access to robust and information-rich human cardiac tissue models would accelerate drug-based
strategies for treating heart disease. Despite significant effort, the generation of high-…

Background— Atrial fibrillation (AF) may recur after pulmonary vein isolation (PVI) as the
result of either recurrent PV conduction or non-PV foci. This study characterized the …

Strategies to decrease sudden cardiac death in patients with left ventricular systolic dysfunction
are evolving. Recent clinical trials have evaluated the role of prophylactic implantable …

Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show considerable promise
for regenerating injured hearts, and we therefore tested their capacity to stably engraft in …

Phase is a descriptor that tracks the progression of a defined region of myocardium through
the action potential and has been demonstrated to be an effective parameter in analyzing …

Background The cardiovascular complications of cancer therapeutics are the focus of the
burgeoning field of cardio‐oncology. A common challenge in this field is the impact of cancer …

Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown reasons,
is linked to intense endurance exercise. Our studies reveal that 6 weeks of swimming or …

Background: Sex differences in the use and outcomes of implantable cardioverter-defibrillators
(ICDs) have not been fully studied. Objective: To examine potential sex differences in ICD …