Bisphosphonates (BPs) and denosumab reduce the risk of spine and nonspine fractures.
Atypical femur fractures (AFFs) located in the subtrochanteric region and diaphysis of the femur …

Reports linking long‐term use of bisphosphonates (BPs) with atypical fractures of the femur
led the leadership of the American Society for Bone and Mineral Research (ASBMR) to …

Toughness is crucial to the structural function of bone. Usually, the toughness of a material
is not just determined by its composition, but by the ability of its microstructure to dissipate …

Background: Osteoarthritis of the knee affects up to 10% of the elderly population. The
condition is frequently treated by intra-articular injection of hyaluronic acid. We performed a …

The mechanism of calcification in bone and related tissues is a matter of current interest. The
mean size and the arrangement of the mineral crystals are important parameters difficult to …

Anabolic effects of PTH have been observed at several skeletal sites in humans by dual x-ray
absorptiometry without differentiating between an actual increase in bone volume and an …

Fibroblast growth factor‐23 (Fgf23) is a bone‐derived hormone, suppressing phosphate
reabsorption and vitamin D hormone (1,25(OH) 2 D 3 ) production in the kidney. It has long …

Osteogenesis imperfecta (OI) is most often caused by mutations in the type I procollagen genes
(COL1A1/COL1A2). We identified two children with substitutions in the type I procollagen …

Secreted protein, acidic, cysteine-rich (SPARC) is a glycoprotein that binds to collagen type I
and other proteins in the extracellular matrix. Using whole-exome sequencing to identify the …

Osteogenesis imperfecta type I (OI-I) represents the mildest form of OI. The collagen I mutations
underlying the disorder can be classified as quantitative mutations that lead to formation …