[PDF][PDF] A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog

JK Ichida, J Blanchard, K Lam, EY Son, JE Chung… - Cell stem cell, 2009 - cell.com
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Antipsychotic drug use and mortality in older adults with dementia

…, GM Anderson, K Sykora, K Lam… - Annals of internal …, 2007 - acpjournals.org
Background: Antipsychotic drugs are widely used to manage behavioral and psychological
symptoms in dementia despite concerns about their safety. Objective: To examine the …

Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation

J Rihel, DA Prober, A Arvanites, K Lam, S Zimmerman… - Science, 2010 - science.org
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small
molecules will alter complex behaviors. We report the development and application of a high-…

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

…, R Maehr, K Osafune, L Davidow, K Lam… - Nature chemical …, 2009 - nature.com
Stepwise differentiation from embryonic stem cells (ESCs) to functional insulin-secreting
beta cells will identify key steps in beta-cell development and may yet prove useful for …

Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome

T Zuo, SH Wong, K Lam, R Lui, K Cheung, W Tang… - Gut, 2018 - gut.bmj.com
Objective Faecal microbiota transplantation (FMT) is effective for the treatment of recurrent
Clostridium difficile infection (CDI). Studies have shown bacterial colonisation after FMT, but …

HBsAg seroclearance further reduces hepatocellular carcinoma risk after complete viral suppression with nucleos (t) ide analogues

TCF Yip, GLH Wong, HLY Chan, YK Tse, KLY Lam… - Journal of …, 2019 - Elsevier
Background & Aims In treated patients with chronic hepatitis B (CHB) who have achieved
complete viral suppression, it is unclear if functional cure as indicated by hepatitis B surface …

[HTML][HTML] Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection

T Zuo, SH Wong, CP Cheung, K Lam, R Lui… - Nature …, 2018 - nature.com
Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile
infection (CDI). Bacterial colonization in recipients after FMT has been studied, but little is …

[HTML][HTML] Describing the linkages of the immigration, refugees and citizenship Canada permanent resident data and vital statistics death registry to Ontario's …

M Chiu, M Lebenbaum, K Lam, N Chong… - BMC medical informatics …, 2016 - Springer
Background Ontario, the most populous province in Canada, has a universal healthcare
system that routinely collects health administrative data on its 13 million legal residents that is …

Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication

JP Annes, JH Ryu, K Lam, PJ Carolan… - Proceedings of the …, 2012 - National Acad Sciences
Diabetes is a pathological condition characterized by relative insulin deficiency, persistent
hyperglycemia, and, consequently, diffuse micro- and macrovascular disease. One …

Mental health service use among children and youth in Ontario: population-based trends over time

S Gandhi, M Chiu, K Lam, JC Cairney… - The Canadian …, 2016 - journals.sagepub.com
Objective: Little is known about mental health service use among Canadian children and
youth. Our objective was to examine temporal trends in mental health service use across …