User profiles for Keith Fowke
 | Keith FowkeProfessor of Medical Microbiology and Infectious Diseases, University of Manitoba Verified email at umanitoba.ca Cited by 8401 |
Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how HIV …
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how HIV …
Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
Background There is indirect evidence that HIV-1 exposure does not inevitably lead to persistent
infection. Heterogeneity in susceptibility to infection could be due to protective immunity…
infection. Heterogeneity in susceptibility to infection could be due to protective immunity…
Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi.
Many people who remain persistently seronegative despite frequent HIV exposure have HIV-specific
immune responses. The study of these may provide information about mechanisms …
immune responses. The study of these may provide information about mechanisms …
Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell
recognition, may, in part, account for the observed differences in human immunodeficiency …
recognition, may, in part, account for the observed differences in human immunodeficiency …
Isolation of rhododaurichromanic acid B and the anti-HIV principles rhododaurichromanic acid A and rhododaurichromenic acid from Rhododendron dauricum
…, K Mihashi, K Mizuki, LM Cosentino, K Fowke… - Tetrahedron, 2001 - Elsevier
Two novel chromane derivatives (1 and 2) and the known chromene (3) were isolated from
the leaves and twigs of Rhododendron dauricum. The absolute stereostructure of 1 was …
the leaves and twigs of Rhododendron dauricum. The absolute stereostructure of 1 was …
[HTML][HTML] LAG3's enigmatic mechanism of action
CG Graydon, S Mohideen, KR Fowke - Frontiers in immunology, 2021 - frontiersin.org
LAG3 is an important immune checkpoint with relevance in cancer, infectious disease and
autoimmunity. However, despite LAG3’s role in immune exhaustion and the great potential of …
autoimmunity. However, despite LAG3’s role in immune exhaustion and the great potential of …
Invariant NKT cells: regulation and function during viral infection
Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural
killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), …
killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), …
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …
Decreased Immune Activation in Resistance to HIV-1 Infection Is Associated with an Elevated Frequency of CD4+CD25+FOXP3+ Regulatory T Cells
Human immunodeficiency virus (HIV)–resistant commercial sex workers provide a unique
opportunity to study correlates of protection associated with natural resistance to HIV infection. …
opportunity to study correlates of protection associated with natural resistance to HIV infection. …
Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract
Objective: There is substantial epidemiological evidence that infection by Herpes simplex
virus type 2 (HSV2) enhances both HIV susceptibility and subsequent sexual transmission. …
virus type 2 (HSV2) enhances both HIV susceptibility and subsequent sexual transmission. …
