[HTML][HTML] Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation
SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics …
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics …
Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
A Hodges, K Sharrocks, M Edelmann, D Baban… - Nature …, 2007 - nature.com
DC-SIGN, a C-type lectin expressed on dendritic cells (DCs), can sequester human
immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene …
immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene …
The removal of airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other microbial bioaerosols by air filtration on coronavirus disease 2019 …
A Conway Morris, K Sharrocks… - Clinical Infectious …, 2022 - academic.oup.com
Airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in a
coronavirus disease 19 (COVID-19) ward before activation of HEPA-air filtration but not …
coronavirus disease 19 (COVID-19) ward before activation of HEPA-air filtration but not …
[PDF][PDF] Point of care nucleic acid testing for SARS-CoV-2 in hospitalized patients: a clinical validation trial and implementation study
…, SM Assennato, B Warne, N Sithole, K Sharrocks… - Cell Reports …, 2020 - cell.com
There is an urgent need for rapid SARS-CoV-2 testing in hospitals to limit nosocomial spread.
We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in …
We report an evaluation of point of care (POC) nucleic acid amplification testing (NAAT) in …
[HTML][HTML] The removal of airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other microbial bioaerosols by air filtration on coronavirus …
AC Morris, K Sharrocks, R Bousfield… - … Diseases: An Official …, 2022 - ncbi.nlm.nih.gov
Airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in a
coronavirus disease 19 (COVID-19) ward before activation of HEPA-air filtration but not …
coronavirus disease 19 (COVID-19) ward before activation of HEPA-air filtration but not …
[HTML][HTML] Rebooting medical education with virtual grand rounds during the COVID-19 pandemic
Social distancing during the coronavirus disease 2019 (COVID-19) pandemic has necessitated
drastic changes in the practice of hospital medicine, including the cancellation of many …
drastic changes in the practice of hospital medicine, including the cancellation of many …
[HTML][HTML] A prospective study of risk factors associated with seroprevalence of SARS-CoV-2 antibodies in healthcare workers at a large UK teaching hospital
…, M Ferris, R Doffinger, R Bousfield, K Sharrocks… - Journal of Infection, 2022 - Elsevier
Objectives : To describe the risk factors for SARS-CoV-2 infection in UK healthcare workers (HCWs).
Methods : We conducted a prospective sero-epidemiological study of HCWs at a …
Methods : We conducted a prospective sero-epidemiological study of HCWs at a …
[HTML][HTML] Applying prospective genomic surveillance to support investigation of hospital-onset COVID-19
…, S Coscione, C Myers, K Sharrocks… - The Lancet Infectious …, 2021 - thelancet.com
Here, we provide an update on our previous Article, 1 which described the use of rapid
SARS-CoV-2 genome sequencing to investigate hospital-acquired infections (HAIs) at …
SARS-CoV-2 genome sequencing to investigate hospital-acquired infections (HAIs) at …
[HTML][HTML] Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling
A Simmons, B Gangadharan, A Hodges, K Sharrocks… - Immunity, 2005 - cell.com
Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus
involved is incompletely described. We explored CD4 T cell lipid raft composition in the …
involved is incompletely described. We explored CD4 T cell lipid raft composition in the …
[HTML][HTML] A mycotic aneurysm related to Salmonella Rissen infection: a case report
J Nagrodzki, KE Sharrocks, VK Wong… - BMC Infectious …, 2020 - Springer
Background Salmonella species commonly causes infection in humans and on occasion
leads to serious complications, such as mycotic aneurysms. Here, we present the first case …
leads to serious complications, such as mycotic aneurysms. Here, we present the first case …