The World Medical Association is now debating the next revision of the Declaration of Helsinki.
Kenneth Rothman and Karin Michels argue that critics of the declaration, notably the US …

Background: Several recent large prospective cohort studies have failed to demonstrate the
presumed protective effect of fruit, vegetable, and dietary fiber consumption on colorectal …

Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

Is it ethical to use a placebo? The answer to this question will depend, I suggest, upon whether
there is already available an orthodox treatment of proved or accepted value. If there is …

Background: The Women's Health Initiative randomized trial found greater coronary heart
disease (CHD) risk in women assigned to estrogen/progestin therapy than in those assigned …

ContextLactation is associated with improved glucose and insulin homeostasis, independent
of weight change.ObjectiveTo evaluate the association between lactation history and …

Background: Frequent consumption of fruit and vegetables has been associated with a
reduced risk of colorectal cancer in many observational studies. Methods: We prospectively …

BACKGROUND: The remarkable similarity of lifestyle and environmental risk factors for type
2 (non-insulin-dependent) diabetes mellitus and colon cancer has led to the hypothesis that …

OBJECTIVE—Hyperinsulinemia may promote mammary carcinogenesis. Insulin resistance
has been linked to an increased risk of breast cancer and is also characteristic of type 2 …

We assessed the reproducibility and validity of a questionnaire that asks mothers to recall
pregnancy-related events from thirty or more years ago. Among 146 women who completed …