Objective To establish whether an association exists between use of selective serotonin
reuptake inhibitors (SSRIs) and suicide attempts. Design Systematic review of randomised …

Objective To examine the reporting and success of double blinding in a sample of randomised,
placebo controlled trials from leading general medicine and psychiatry journals. Methods …

Bromodomain proteins function as epigenetic readers that recognize acetylated histone
tails to facilitate the transcription of target genes. There are approximately 60 known human …

Prospective epidemiologic studies aid in identifying genetic variants associated with diseases,
health risks, and physiologic traits. These genetic variants may eventually be measured …

Background Aprotinin is a serine protease inhibitor used to limit perioperative bleeding and
reduce the need for donated blood transfusions during cardiac surgery. Randomized …

The ethical basis for entering patients in randomised controlled trials is under debate. Some
doctors espouse the uncertainty principle whereby randomisation to treatment is acceptable …

The semistructured, open-ended interview has become the gold standard for qualitative health
research. Despite its strengths, the long interview is not well suited for studying topics that …

Histone acetyltransferases (HATs) assemble into multisubunit complexes in order to target
distinct lysine residues on nucleosomal histones. Here, we characterize native HAT …

We present a detailed analysis of the luminescence behavior of europium-doped hydroxyapatite
(HAp) and calcium-deficient hydroxyapatite (Ca-D HAp) nanopowders. The results …

… And yet, to understand effectiveness in this way is absurd; by this measure, flinging a glass
of water at a burning building is an effective fire-fighting strategy because it is better than …