Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays critical roles in
integrin-mediated signal transductions and also participates in signaling by other cell surface …

Cellular interactions with extracellular matrix play essential roles in tumor initiation, progression
and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase identified …

… It should be noted that the major pathway downstream of Crk that has been identified
results in activation of the JNK (Jun N-terminal kinase) family of MAP kinases (113, 114); …

The in vitro scratch assay is an easy, low-cost and well-developed method to measure cell
migration in vitro. The basic steps involve creating a “scratch” in a cell monolayer, capturing …

Autophagy is an intracellular degradation system, by which cytoplasmic contents are
degraded in lysosomes. Autophagy is dynamically induced by nutrient depletion to provide …

N 6 -methyladenosine (m 6 A) is the most prevalent modification in eukaryotic messenger
RNAs (mRNAs) and is interpreted by its readers, such as YTH domain-containing proteins, to …

Autophagy is a membrane-mediated intracellular degradation system. The serine/threonine
kinase Atg1 plays an essential role in autophagosome formation. However, the role of the …

INCREASING evidence indicates that the integrin family of cell adhesion receptors can
transduce biochemical signals from the extracellular matrix to the cell interior to modulate cell …

Recent evidence suggests that breast cancer and other solid tumors possess a rare population
of cells capable of extensive self-renewal that contribute to metastasis and treatment …

The wound-healing assay is simple, inexpensive, and one of the earliest developed methods
to study directional cell migration in vitro. This method mimics cell migration during wound …