The 1918 influenza pandemic was unusually severe, resulting in about 50 million deaths
worldwide 1 . The 1918 virus is also highly pathogenic in mice, and studies have identified a …

Without an approved vaccine or treatments, Ebola outbreak management has been limited
to palliative care and barrier methods to prevent transmission. These approaches, however, …

AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1
and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how HIV …

Background The worst Ebola virus disease (EVD) outbreak in history has resulted in more
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …

Ebola virus (EBOV) is considered one of the most aggressive infectious agents and is capable
of causing death in humans and nonhuman primates (NHPs) within days of exposure. …

Tick-borne Crimean-Congo hemorrhagic fever virus (CCHFV) causes a severe hemorrhagic
syndrome in humans but not in its vertebrate animal hosts. The pathogenesis of the disease …

Many cell death pathways converge at the mitochondria to induce release of apoptogenic
proteins and permeability transition, resulting in the activation of effector caspases responsible …

Ebola virus causes severe hemorrhagic fever in susceptible hosts. Currently, no licensed
vaccines or treatments are available; however, several experimental vaccines have been …

Background Zaire ebolavirus (ZEBOV) produces a lethal viral hemorrhagic fever in humans
and non-human primates. Methodology/Principal Findings We demonstrate that the VSVΔG/…

Zaire ebolavirus (ZEBOV) can be transmitted by human-to-human contact and causes acute
haemorrhagic fever with case fatality rates up to 90%. There are no effective therapeutic or …