Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background Cardiopulmonary bypass initiates a systemic inflammatory response syndrome
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …

Objectives : We conducted a systematic review and meta-analysis to determine if pre-operative
brain natriuretic peptide (BNP) (ie, BNP or N-terminal pro–B-type natriuretic peptide [NT-…

Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …

Background There is uncertainty regarding the prognostic value of troponin and creatine
kinase muscle and brain isoenzyme measurements after noncardiac surgery. Methods The …

BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …

Background Prevention of chronic chagasic cardiomyopathy (CCC) by treating infected
populations with trypanocidal therapy (TT) remains a challenge. Despite a renewed enthusiasm …

Neglected diseases remain one of the largest causes of disease and mortality. In addition to
the difficulties in provision of appropriate drugs for specific diseases, many other factors …