[HTML][HTML] Normothermic ex vivo lung perfusion in clinical lung transplantation

M Cypel, JC Yeung, M Liu, M Anraku… - New England journal …, 2011 - Mass Medical Soc
Background More than 80% of donor lungs are potentially injured and therefore not considered
suitable for transplantation. With the use of normothermic ex vivo lung perfusion (EVLP), …

Technique for prolonged normothermic ex vivo lung perfusion

M Cypel, JC Yeung, S Hirayama, M Rubacha… - The Journal of heart and …, 2008 - Elsevier
BACKGROUND: The inhibition of cellular metabolism induced by hypothermia obviates the
possibility of substantial reparative processes occurring during organ preservation. The aim …

[HTML][HTML] Experience with the first 50 ex vivo lung perfusions in clinical transplantation

M Cypel, JC Yeung, T Machuca, M Chen… - The Journal of thoracic …, 2012 - Elsevier
OBJECTIVE: Normothermic ex vivo lung perfusion is a novel method to evaluate and improve
the function of injured donor lungs. We reviewed our experience with 50 consecutive …

Functional repair of human donor lungs by IL-10 gene therapy

M Cypel, M Liu, M Rubacha, JC Yeung… - Science translational …, 2009 - science.org
More than 80% of potential donor lungs are injured during brain death of the donor and
from complications experienced in the intensive care unit, and therefore cannot be used for …

Functional Production and Characterization of a Fibrin-Specific Single-Chain Antibody Fragment from Bacillus subtilis: Effects of Molecular Chaperones and a Wall …

SC Wu, JC Yeung, Y Duan, R Ye… - Applied and …, 2002 - Am Soc Microbiol
Jonathan C. Yeung was supported in part by summer studentships from both Alberta
Heritage Foundation of Medical Research (AHFMR) and Natural Science and Engineering …

Physiologic assessment of the ex vivo donor lung for transplantation

JC Yeung, M Cypel, TN Machuca, T Koike… - The Journal of Heart and …, 2012 - Elsevier
… Author links open overlay panel Jonathan C. Yeung MD, PhD a , Marcelo Cypel MD a ,
Tiago N. Machuca MD, PhD a , Terumoto Koike MD, PhD a , Douglas J. Cook MD, PhD a , …

Outcomes after transplantation of lungs preserved for more than 12 h: a retrospective study

JC Yeung, T Krueger, K Yasufuku… - The Lancet …, 2017 - thelancet.com
Background Ex-vivo lung perfusion (EVLP) can be used to extend overall lung preservation
time by splitting one long cold ischaemic time into two shorter ones and interposing an …

Long-term outcomes of lung transplant with ex vivo lung perfusion

…, M de Perrot, A Pierre, K Yasufuku, JC Yeung… - JAMA …, 2019 - jamanetwork.com
Importance The mortality rate for individuals on the wait list for lung transplant is 15% to 25%,
and still only 20% of lungs from multiorgan donors are used for lung transplant. The lung …

[HTML][HTML] Extracorporeal life support as a bridge to lung transplantation–experience of a high-volume transplant center

K Hoetzenecker, L Donahoe, JC Yeung, S Azad… - The Journal of thoracic …, 2018 - Elsevier
Objectives Extracorporeal life support (ECLS) is increasingly used to bridge deteriorating
patients awaiting lung transplantation (LTx), however, few systematic descriptions of this …

[HTML][HTML] Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre-and post–lung transplantation in the pig

JC Yeung, D Wagnetz, M Cypel, M Rubacha, T Koike… - Molecular Therapy, 2012 - cell.com
Acellular normothermic ex vivo lung perfusion (EVLP) is a novel method of donor lung
preservation for transplantation. As cellular metabolism is preserved during perfusion, it …