User profiles for John Muscedere

John Muscedere

Queen's University
Verified email at kingstonhsc.ca
Cited by 18072

Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America …

…, ML Metersky, M Klompas, J Muscedere… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

[HTML][HTML] A randomized trial of glutamine and antioxidants in critically ill patients

D Heyland, J Muscedere, PE Wischmeyer… - … England Journal of …, 2013 - Mass Medical Soc
Background Critically ill patients have considerable oxidative stress. Glutamine and antioxidant
supplementation may offer therapeutic benefit, although current data are conflicting. …

Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia

…, D Heyland, M Jacka, L Hand, J Muscedere… - Annals of Internal …, 2004 - acpjournals.org
Background: Ventilator-associated pneumonia (VAP) is an important patient safety issue in
critically ill patients. Purpose: To develop an evidence-based guideline for the prevention of …

[HTML][HTML] The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis

J Muscedere, B Waters, A Varambally… - Intensive care …, 2017 - Springer
Purpose Functional status and chronic health status are important baseline characteristics
of critically ill patients. The assessment of frailty on admission to the intensive care unit (ICU) …

Executive summary: management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases …

…, ML Metersky, M Klompas, J Muscedere… - Clinical Infectious …, 2016 - academic.oup.com
It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

[HTML][HTML] Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care …

SP Keenan, T Sinuff, KEA Burns, J Muscedere… - Cmaj, 2011 - Can Med Assoc
© 2011 Canadian Medical Association or its licensors CMAJ, February 22, 2011, 183 (3)
E195 backgrounds in clinical and/or nonclinical expertise: 15 were experts in critical care …

Comprehensive evidence-based clinical practice guidelines for ventilator-associated pneumonia: prevention

J Muscedere, P Dodek, S Keenan, R Fowler… - Journal of critical …, 2008 - Elsevier
BACKGROUND: Ventilator-associated pneumonia (VAP) is an important cause of morbidity
and mortality in ventilated critically ill patients. PURPOSE: To develop evidence-based …

Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis

J Muscedere, O Rewa, K Mckechnie, X Jiang… - Critical care …, 2011 - journals.lww.com
Background and Purpose: Aspiration of secretions containing bacterial pathogens into the
lower respiratory tract is the main cause of ventilator-associated pneumonia. Endotracheal …

Effect of probiotics on incident ventilator-associated pneumonia in critically ill patients: a randomized clinical trial

…, ME Wilcox, A Goffi, HT Stelfox, D Niven, J Muscedere… - Jama, 2021 - jamanetwork.com
Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Mortality, attributable mortality, and clinical events as end points for clinical trials of ventilator-associated pneumonia and hospital-acquired pneumonia

JG Muscedere, A Day… - Clinical infectious …, 2010 - academic.oup.com
Appropriate end points are crucial for the successful interpretation of clinical trials. Choosing
end points for therapeutic trials of ventilator-associated pneumonia (VAP) and hospital-…