User profiles for John Lear

John T Lear

- Verified email at mcht.nhs.uk - Cited by 11052

John Lear

- Verified email at pugetsound.edu - Cited by 929

Non-melanoma skin cancer

V Madan, JT Lear, RM Szeimies - The lancet, 2010 - thelancet.com
The rising incidence and morbidity of non-melanoma skin cancers has generated great
interest in unravelling of their pathogenesis and in the search for new non-invasive treatments. …

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind …

…, R Plummer, ALS Chang, F Cornélis, JT Lear… - The Lancet …, 2015 - thelancet.com
Background Patients with advanced basal cell carcinoma have limited treatment options.
Hedgehog pathway signalling is aberrantly activated in around 95% of tumours. We assessed …

Association between functional polymorphism in EGF gene and malignant melanoma

…, RC Strange, PE Hutchinson, JE Osborne, JT Lear… - The Lancet, 2002 - thelancet.com
Background Malignant melanoma, the most serious cutaneous malignancy, has attracted
substantial attention because of its rapidly increasing incidence and the poor prognosis of …

[BOOK][B] Workers, Neighbors, and Citizens: The Revolution in Mexico City

J Lear - 2001 - books.google.com
John Lear addresses a basic paradox: During one of the great … ř Lear identifies a significant
and largely underestimated tradition … Lear suggests that the prominence of labor after the …

Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma

PE Hutchinson, JE Osborne, JT Lear, AG Smith… - Clinical Cancer …, 2000 - AACR
Calcitriol[1,25(OH) 2 D 3 ], the hormonal derivative of vitamin D 3 , is an antiproliferative and
prodifferentiation factor for several cell types, including cultured melanocytes and malignant …

[HTML][HTML] The 12-month analysis from Basal Cell Carcinoma Outcomes with LDE225 Treatment (BOLT): a phase II, randomized, double-blind study of sonidegib in …

…, F Cornélis, R Kudchadkar, U Trefzer, JT Lear… - Journal of the American …, 2016 - Elsevier
Background The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor
shrinkage in more than 90% of patients with locally advanced basal cell carcinoma (BCC) or …

British Association of Dermatologists guidelines for the management of adults with basal cell carcinoma 2021

…, G Gupta, M Hashme, S Hoey, JT Lear… - British Journal of …, 2021 - academic.oup.com
British Association of Dermatologists guidelines for the management of adults with basal cell
carcinoma 2021* | British Journal of Dermatology | Oxford Academic Skip to Main Content …

[HTML][HTML] Non-melanoma skin cancer

LL Griffin, FR Ali, JT Lear - Clinical medicine, 2016 - ncbi.nlm.nih.gov
Non-melanoma skin cancer (NMSC) comprises basal cell carcinoma (BCC) and squamous
cell carcinoma, together with a host of rare tumours. NMSC is the commonest malignancy …

[HTML][HTML] Emerging trends in the treatment of advanced basal cell carcinoma

…, ALS Chang, L Dirix, AJ Stratigos, JT Lear - Cancer treatment …, 2018 - Elsevier
Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most
patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic …

Associations between ultraviolet radiation, basal cell carcinoma site and histology, host characteristics, and rate of development of further tumors

TJ Lovatt, JT Lear, J Bastrilles, C Wong… - Journal of the American …, 2005 - Elsevier
BACKGROUND: Patients with basal cell carcinoma (BCC) frequently develop further tumors
during follow-up. OBJECTIVE: We sought to elucidate the relative effects of pattern of …