User profiles for John Goffin
 | John GoffinMcMaster University Verified email at medportal.ca Cited by 6907 |
[HTML][HTML] Probability of cancer in pulmonary nodules detected on first screening CT
…, J Yee, J English, P Nasute, J Goffin… - New England journal …, 2013 - Mass Medical Soc
Background Major issues in the implementation of screening for lung cancer by means of
low-dose computed tomography (CT) are the definition of a positive result and the …
low-dose computed tomography (CT) are the definition of a positive result and the …
Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer
…, PO Chappuis, LR Bégin, JR Goffin… - Journal of the …, 2003 - academic.oup.com
A basal epithelial phenotype is found in not more than 15% of all invasive breast cancers.
Microarray studies have shown that this phenotype is associated with breast cancers that …
Microarray studies have shown that this phenotype is associated with breast cancers that …
The Prognostic Implication of the Basal-Like (Cyclin Ehigh/p27low/p53+/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1-Related Breast Cancer
…, PO Chappuis, LR Bégin, N Hamel, JR Goffin… - Cancer research, 2004 - AACR
Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors
that do not express estrogen receptors, HER2, p27 Kip1 , or cyclin D1, but do express p53 …
that do not express estrogen receptors, HER2, p27 Kip1 , or cyclin D1, but do express p53 …
Effect of combined immune checkpoint inhibition vs best supportive care alone in patients with advanced colorectal cancer: the Canadian Cancer Trials Group CO. 26 …
…, SR Berry, F Couture, CE Ahmad, JR Goffin… - JAMA …, 2020 - jamanetwork.com
Importance Single-agent immune checkpoint inhibition has not shown activities in advanced
refractory colorectal cancer (CRC), other than in those patients who are microsatellite-…
refractory colorectal cancer (CRC), other than in those patients who are microsatellite-…
[HTML][HTML] A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant …
…, J Satagopan, N Wong, J Boyd, JR Goffin… - Breast Cancer …, 2003 - Springer
Background The prognostic significance of germline mutations in BRCA1 and BRCA2 in
women with breast cancer remains unclear. A combined analysis was performed to address this …
women with breast cancer remains unclear. A combined analysis was performed to address this …
Participant selection for lung cancer screening by risk modelling (the Pan-Canadian Early Detection of Lung Cancer [PanCan] study): a single-arm, prospective study
…, H Schmidt, S Martel, A McWilliams, JR Goffin… - The lancet …, 2017 - thelancet.com
Background Results from retrospective studies indicate that selecting individuals for low-dose
CT lung cancer screening on the basis of a highly predictive risk model is superior to using …
CT lung cancer screening on the basis of a highly predictive risk model is superior to using …
[HTML][HTML] First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: a systematic review
Introduction Non-small cell lung cancer (NSCLC) frequently presents at an incurable stage,
and a majority of patients will be considered for palliative chemotherapy at some point in …
and a majority of patients will be considered for palliative chemotherapy at some point in …
[HTML][HTML] The cost-effectiveness of high-risk lung cancer screening and drivers of program efficiency
Introduction Lung cancer risk prediction models have the potential to make programs more
affordable; however, the economic evidence is limited. Methods Participants in the National …
affordable; however, the economic evidence is limited. Methods Participants in the National …
Cost-effectiveness of lung cancer screening in Canada
JR Goffin, WM Flanagan, AB Miller… - JAMA …, 2015 - jamanetwork.com
Importance The US National Lung Screening Trial supports screening for lung cancer among
smokers using low-dose computed tomographic (LDCT) scans. The cost-effectiveness of …
smokers using low-dose computed tomographic (LDCT) scans. The cost-effectiveness of …
Epidermal growth factor receptor: pathway, therapies, and pipeline
JR Goffin, K Zbuk - Clinical therapeutics, 2013 - Elsevier
Background The epidermal growth factor receptor (EGFR) pathway is important in tumor
growth, survival, and metastasis and is now the target of several therapeutic agents. Objectives …
growth, survival, and metastasis and is now the target of several therapeutic agents. Objectives …