Background Valdecoxib and its intravenous prodrug parecoxib are used to treat postoperative
pain but may involve risk after coronary-artery bypass grafting (CABG). We conducted a …

Background There is substantial variability in the perioperative administration of aspirin in
patients undergoing noncardiac surgery, both among patients who are already on an aspirin …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to
the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia, …

Background Marked activation of the sympathetic nervous system occurs during and after
noncardiac surgery. Low-dose clonidine, which blunts central sympathetic outflow, may …

Background The relative contributions of intraoperative and postoperative hypotension to
perioperative morbidity remain unclear. We determined the association between hypotension …

Background: Among patients having noncardiac surgery, perioperative hemodynamic
abnormalities are associated with vascular complications. Uncertainty remains about what …

Background: Uncertainty remains about the effects of aspirin in patients with prior percutaneous
coronary intervention (PCI) having noncardiac surgery. Objective: To evaluate benefits …

Background The “obesity paradox” reflects an observed relationship between obesity and
decreased morbidity and mortality, suggesting improved health outcomes for obese individuals…

Background Consensus recommendations regarding the threshold levels of cardiac troponin
elevations for the definition of perioperative myocardial infarction and clinically important …