Rationale: Diaphragm atrophy and dysfunction have been reported in humans during
mechanical ventilation, but the prevalence, causes, and functional impact of changes in …

External ventricular drains (EVDs) are commonly placed to monitor intracranial pressure
and manage acute hydrocephalus in patients with a variety of intracranial pathologies. The …

Objectives: To assess the knowledge and use of the Assessment, prevention, and management
of pain; spontaneous awakening and breathing trials; Choice of analgesia and sedation; …

Objectives The American–European consensus conference (AECC) definition for acute
respiratory distress syndrome (ARDS) requires a PaO 2 /F I O 2 ≤200 mmHg, regardless of …

Rationale: It is commonly stated that mortality from acute respiratory distress syndrome (ARDS)
and acute lung injury (ALI) is decreasing. Objectives: To systematically review the …

A decision to withdraw life-sustaining treatment (WLST) is derived by a conclusion that further
treatment will not enable a patient to survive or will not produce a functional outcome with …

Introduction A strong biologic rationale exists for targeting markers of endothelial cell (EC)
activation as clinically informative biomarkers to improve diagnosis, prognostic evaluation or …

Background: Little is known about the risks of urgent air–medical transport used in regionalized
health care systems. We sought to determine the incidence of intransit critical events and …

Study Design: Systematic review and meta-analysis. Objective: The objective of this study was
to conduct a systematic review to assess the comparative effectiveness and safety of high-…

Study objective The risks associated with urgent land-based transport of critically ill patients
are not well known and have important implications for patient safety, care delivery, and …