Background It is common practice to restore and maintain sinus rhythm in patients with atrial
fibrillation and heart failure. This approach is based in part on data indicating that atrial …

Background. Left ventricular dilatation and dysfunction after myocardial infarction are major
predictors of death. In experimental and clinical studies, long-term therapy with the …

Background In patients with high cholesterol levels, lowering the cholesterol level reduces
the risk of coronary events, but the effect of lowering cholesterol levels in the majority of …

Background We compared the angiotensin receptor–neprilysin inhibitor LCZ696 with
enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, …

Background Lipid-lowering therapy with statins reduces the risk of cardiovascular events,
but the optimal level of low-density lipoprotein (LDL) cholesterol is unclear. Methods We …

Background Beta-blocking agents reduce the risk of hospitalization and death in patients with
mild-to-moderate heart failure, but little is known about their effects in severe heart failure. …

Background Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce mortality
and cardiovascular morbidity among patients with myocardial infarction complicated by …

Background The presence of coexisting conditions has a substantial effect on the outcome of
acute myocardial infarction. Renal failure is associated with one of the highest risks, but the …

Background Cardiac-resynchronization therapy (CRT) benefits patients with left ventricular
systolic dysfunction and a wide QRS complex. Most of these patients are candidates for an …

ContextLimited data are available evaluating how the timing and intensity of statin therapy
following an acute coronary syndrome (ACS) event affect clinical outcome.ObjectiveTo …