The major motor disturbances in Parkinson's disease are thought to be caused by overactivity
of the internal segment of the globus pallidus (GPi), in large part due to excessive drive …

Objective To compare initial treatment with pramipexole vs levodopa in early Parkinson
disease, followed by levodopa supplementation, with respect to the development of …

Dementia is an important and increasingly recognized problem in Parkinson's disease (PD).
The mini‐mental state examination (MMSE) often fails to detect early cognitive decline. The …

As no comprehensive assessment instrument for impulse control disorders (ICDs) in Parkinson's
disease (PD) exists, the aim of this study was to design and assess the psychometric …

… Critical revision of the manuscript for important intellectual content: Voon, Thomsen, Miyasaki,
de Souza, Fox, Duff-Canning, Lang, and Zurowski. Statistical analysis: Shafro and Fox. …

Calcifications in the basal ganglia are a common incidental finding and are sometimes inherited
as an autosomal dominant trait (idiopathic basal ganglia calcification (IBGC)). Recently, …

Importance Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has
been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine …

Objective: The chemotherapeutic agent mitoxantrone was approved for use in multiple
sclerosis (MS) in 2000. After a review of all the available evidence, the original report of the …

… Janis M. Miyasaki: drafting and revising the manuscript for intellectual content. Jeff A. Sloan:
… Miyasaki receives grants through PCORI and Parkinson Alberta and is a member of the …

Objective: To determine if transcutaneous electric nerve stimulation (TENS) is efficacious in
the treatment of pain in neurologic disorders. Methods: We performed a systematic literature …