A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation
of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown …

A new compound has been found, (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine ((S)-HPMPA),
that has potent and selective activity against a broad spectrum of DNA viruses, …

Several 4-or 5-monosubsituted and 4, 5-disubstituted 1, 2, 3-triazole analogues of the anti-HIV-1
lead compound [l-[2,, 5,-bis-0-(ieri-butyldimethylsilyl)-/?-D-ribofuranosyl] thymine]-3'-…

The sulfated polysaccharides dextran sulfate and heparin have proved to be potent and
selective inhibitors of human immunodeficiency virus type 1 (HIV-1) in vitro. Dextran sulfate (Mr …

Various 3-hydroxy-2-phosphonylmethoxypropyl (HPMP) and 2-phosphonylmethoxyethyl (PME)
derivatives of purine [adenine (A), guanine (G), 2,6-diaminopurine (DAP), 2-…

Two prominent members of the ATP-binding cassette superfamily of transmembrane
proteins, multidrug resistance 1 (MDR1) P-glycoprotein and multidrug resistance protein 1 (MRP1), …

PURPOSE: A complete remission (CR) after first-line therapy is associated with longer
progression-free survival (PFS). However, defining CR is not always easy because of the …

The human multidrug resistance proteins MRP4 and MRP5 are organic anion transporters
that have the unusual ability to transport cyclic nucleotides and some nucleoside …

Background Less than half of all patients with aggressive non-Hodgkin’s lymphoma (NHL)
are cured with standard chemotherapy. Therefore, it is important to distinguish between …

As a part of our studies of the utilization of the lithiation reaction for the modification of the
base moiety of nu-cleosides, 21" 32 we were interested in synthesizing 6-sub-stituted uracil …